2-甲基-2-(4-硝基苯基)-丙酸合成路线 （共 8 条）
反应条件
sodium hydroxide in methanol T=60°C; 4 h;
参考文献
Walsh, Thomas F; Toupence, Richard B; Ujjainwalla, Feroze; Young, Jonathan R; Goulet, Mark T
Tetrahedron, 2001 , vol. 57, # 24 p. 5233 - 5241
反应条件
hydrogenchloride in tetrahydrofuran; water 20 h; Heating / reflux;
参考文献
ADDEX PHARMA SA
Patent: WO2008/117175 A2, 2008 ;
Location in patent: Page/Page column 124 ;
WO 2008/117175 A2
反应条件
sodium hydroxide; water in methanol T=40°C; 16 h;
参考文献
Shang, Rui; Huang, Zheng; Chu, Ling; Fu, Yao; Liu, Lei
Organic Letters, 2011 , vol. 13, # 16 p. 4240 - 4243
反应条件
sulfuric acid; water Heating / reflux;
参考文献
F2G LTD
Patent: WO2008/62182 A1, 2008 ;
Location in patent: Page/Page column 120 ;
反应条件
sulfuric acid; nitric acid
参考文献
Overberger; Gainer
Journal of the American Chemical Society, 1958 , vol. 80, p. 4561,4564
反应条件
1: aqueous NaClO 2: concentrated H2SO4; concentrated aqueous HNO3 View Scheme
参考文献
Overberger; Gainer
Journal of the American Chemical Society, 1958 , vol. 80, p. 4561,4564
反应条件
1: aqueous HNO3 2: aqueous H2SO4 View Scheme
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
hydrogen; palladium on activated carbon in methanol T=20°C; P=2250.23 Torr; 16 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2008/77885 A2, 2008 ;
Location in patent: Page/Page column 23 ;
WO 2008/077885 A2
