2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-4-酮合成路线 （共 8 条）
反应条件
methanol; sodium tetrahydroborate T=20°C;
参考文献
Charron, Catherine Elisabeth; Fenton, Robert; Crowe, Scott; Ito, Kazuhiro; Strong, Peter; Rapeport, William Garth; Ray, Keith
Patent: US2012/244120 A1, 2012 ;
反应条件
1: in diethyl ether
T=0°C; Reflux;
2: With water in diethyl ether
Cooling;
参考文献
IRM LLC; CHE, Jianwei; CHEN, Bei; DING, Qiang; HAO, Xueshi; HE, Xiaohui; JIANG, Songchun; JIN, Qihui; JIN, Yunho; LIU, Hong; LIU, Yahua; OKRAM, Barun; UNO, Tetsuo; WU, Xu; YANG, Kunyong; ZHU, Xuefeng
Patent: WO2011/14515 A1, 2011 ;
Location in patent: Page/Page column 123 ;
WO 2011/014515 A1
反应条件
methyllithium; Nalco silica sol 1060 in tetrahydrofuran; methanol; diethyl ether; ethyl acetate
参考文献
Charron, Catherine Elisabeth; Fenton, Robert; Crowe, Scott; Ito, Kazuhiro; Strong, Peter; Rapeport, William Garth; Ray, Keith
Patent: US2012/244120 A1, 2012 ;
反应条件
hydrogenchloride
T=75°C; 3 h; Yield given;
参考文献
LaMattina
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 533 - 538
反应条件
1: 55 percent / diethyl ether / 20 h / Ambient temperature
2: 86 percent / p-toluenesulfonic acid / toluene / 16 h / Heating
3: 92 percent / 98percent hydrazine hydrate / 10 h / 110 °C
4: H2/Ra-Ni / ethanol / 4 h / 2280 Torr / Ambient temperature
5: 2N HCl / 3 h / 75 °C
View Scheme
参考文献
LaMattina
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 533 - 538
反应条件
1: 86 percent / p-toluenesulfonic acid / toluene / 16 h / Heating
2: 92 percent / 98percent hydrazine hydrate / 10 h / 110 °C
3: H2/Ra-Ni / ethanol / 4 h / 2280 Torr / Ambient temperature
4: 2N HCl / 3 h / 75 °C
View Scheme
参考文献
LaMattina
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 533 - 538
反应条件
1: 92 percent / 98percent hydrazine hydrate / 10 h / 110 °C
2: H2/Ra-Ni / ethanol / 4 h / 2280 Torr / Ambient temperature
3: 2N HCl / 3 h / 75 °C
View Scheme
参考文献
LaMattina
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 533 - 538
反应条件
1: H2/Ra-Ni / ethanol / 4 h / 2280 Torr / Ambient temperature
2: 2N HCl / 3 h / 75 °C
View Scheme
参考文献
LaMattina
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 533 - 538
