alpha-羟基-3-硝基苯乙酸合成路线 （共 16 条）
反应条件
(benzyl)-tri-(methyl)-ammonium bromide in water; acetic acid T=29.9 - 59.9°C; ΔH, ΔS, ΔG of formation and activation of the intermediate complex with PhCH2Me3NBr3; KineticsMechanismThermodynamic data;
参考文献
Goel, Shruti; Kothari, Seema; Banerji, Kalyan K.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 11 p. 1180 - 1184
反应条件
1: With zinc(II) iodide in dichloromethane
T=0 - 25°C;
2: With hydrogenchloride in water
T=100°C;
参考文献
Campbell, Robert F.; Fitzpatrick, Kevin; Inghardt, Tord; Karlsson, Olle; Nilsson, Kristina; Reilly, John E.; Yet, Larry
Tetrahedron Letters, 2003 , vol. 44, # 29 p. 5477 - 5481
反应条件
hydrogenchloride in water
3 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/48335 A2, 2004 ;
Location in patent: Page 52-53 ;
WO 2004/048335 A2
参考文献
Evans; Witzemann
Journal of the American Chemical Society, 1911 , vol. 33, p. 1773
参考文献
Brode; Adams
Journal of the American Chemical Society, 1926 , vol. 48, p. 2202,2206
反应条件
1: glacial acetic acid
2: hydrochloric acid
View Scheme
参考文献
Brode; Adams
Journal of the American Chemical Society, 1926 , vol. 48, p. 2202,2206
反应条件
1: water; lead nitrate
2: copper acetate
View Scheme
参考文献
Evans; Witzemann
Journal of the American Chemical Society, 1911 , vol. 33, p. 1773
反应条件
acetic acid
man verseift das entstandene Nitril durch Eindampfen mit Salzsaeure;
参考文献
Heller
Chemische Berichte, 1913 , vol. 46, p. 3978
参考文献
Engler; Woehrle
Chemische Berichte, 1887 , vol. 20, p. 2202
参考文献
Beyer
Journal fuer Praktische Chemie (Leipzig), 1885 , vol. <2> 31, p. 384,386
