5-氨基-2-氯苯甲酸甲酯合成路线 （共 9 条）
反应条件
thionyl chloride T=0°C; 12 h; Reflux;
参考文献
Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei
Patent: US2011/257151 A1, 2011 ;
Location in patent: Page/Page column 67 ;
反应条件
hydrogen in ethyl acetate T=50°C; P=7600.51 Torr; 4 h; chemoselective reaction;
参考文献
Takasaki, Mikihiro; Motoyama, Yukihiro; Higashi, Kenji; Yoon, Seong-Ho; Mochida, Isao; Nagashima, Hideo
Organic Letters, 2008 , vol. 10, # 8 p. 1601 - 1604
反应条件
hydrogenchloride; nickel boride in methanol; water 0.0166667 h; Microwave irradiationClosed vessel;
参考文献
Shankaraiah, Nagula; Markandeya, Nagula; Espinoza-Moraga, Marlene; Arancibia, Claudia; Kamal, Ahmed; Santos, Leonardo Silva
Synthesis, 2009 , # 13 art. no. M00709SS, p. 2163 - 2170
反应条件
sodium hydroxide in methanol
参考文献
Merck and Co., Inc.
Patent: US5750549 A1, 1998 ;
US 5750549 A
反应条件
hydrogenchloride in ethanol; dichloromethane; water; ethyl acetate
参考文献
Rhone-Poulenc Rorer S.A.
Patent: US5382590 A1, 1995 ;
反应条件
1: hydrogenchloride / water; 1,4-dioxane / 3 h 2: SnCl2·2H2O; ethanol / 2 h / |Sealed tube; |Sonication View Scheme
参考文献
FLYNN, Gary, A.
Patent: WO2013/22766 A1, 2013 ;
WO 2013/022766 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 66°C; 2 h;
参考文献
Braese, Stefan; Dahmen, Stefan; Popescu, Crisan; Schroen, Maarten; Wortmann, Franz-Josef
Chemistry - A European Journal, 2004 , vol. 10, # 21 p. 5285 - 5296
反应条件
1: 5-amino-2-chloro-benzoic acid methyl ester With hydrogenchloride; sodium nitrite in water T=0°C; 2: furfural With copper dichloride in water T=0 - 20°C;
参考文献
He, Lingyan; Zhang, Liang; Liu, Xiaofeng; Li, Xianghua; Zheng, Mingyue; Li, HongLin; Yu, Kunqian; Chen, Kaixian; Shen, Xu; Jiang, Hualiang; Liu, Hong
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2465 - 2481
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetic acid
T=0°C; 0.75 h;
2: With sulfur dioxide; copper dichloride in water; acetic acid
T=-5 - 20°C; 12 h;
3: With ammonia in tetrahydrofuran; water
T=0°C; 0.25 h;
参考文献
Asubio Pharma Co., Ltd.; Daiichi Sankyo Company, Limited
Patent: EP2025672 A1, 2009 ;
Location in patent: Page/Page column 49-50 ;
