4-氯-2-硝基苯甲酸甲酯合成路线 （共 12 条）
反应条件
potassium carbonate in acetone Esterification; 0.5 h; Heating;
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
sulfuric acid Reflux;
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
参考文献
Cohen; Mc Candlish
Journal of the Chemical Society, 1905 , vol. 87, p. 1271
反应条件
copper(I) oxide; sodium azide; L-proline in dimethyl sulfoxide T=100°C; 2 h; Inert atmosphere;
参考文献
Markiewicz, John T.; Wiest, Olaf; Helquist, Paul
Journal of Organic Chemistry, 2010 , vol. 75, # 14 p. 4887 - 4890
反应条件
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C 2.1: 95 percent / pyridine / 20 °C 3.1: 100 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 4.1: t-BuOK / toluene / 0.5 h / Heating 4.2: 51 percent / conc. HCl / acetic acid / 5 h / Heating 5.1: 82 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C View Scheme
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
potassium fluoride; tetra-phenylphosphonium bromide in dimethyl sulfoxide T=130°C; 27 h;
参考文献
Journal of Fluorine Chemistry, , vol. 63, # 1-2 p. 25 - 30
反应条件
potassium fluoride; tetra-phenylphosphonium bromide in sulfolane T=220°C; 0.5 h; other chloronitroaromatic compounds, other reagents and solvents, var. temp. and time; Product distribution;
参考文献
Journal of Fluorine Chemistry, , vol. 63, # 1-2 p. 25 - 30
反应条件
N-methylhexamethylenetetrammonium fluoride in dimethyl sulfoxide T=100°C; 2 h;
参考文献
Journal of Fluorine Chemistry, , vol. 78, # 1 p. 91 - 93
反应条件
potassium fluoride; tetra-phenylphosphonium bromide in dimethyl sulfoxide T=130°C; 27 h;
参考文献
Journal of Fluorine Chemistry, , vol. 63, # 1-2 p. 25 - 30
反应条件
water; sodium carbonate; [(P{(C6H11)3})2Pd(Cl)2] in acetonitrile
T=150°C; 0.0833333 h; Irradiation;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/52722 A1, 2006 ;
Location in patent: Page/Page column 123 ;
WO 2006/052722 A1
