DL-1-(2-呋喃基)乙醇合成路线 （共 62 条）
反应条件
1: 1-(furan-2-yl)-1-ethanol With H3[PW12O40] in dimethyl sulfoxide
T=100°C; 1 h; Inert atmosphere;
2: para-bromoacetophenone With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triethylamine; [(t-Bu)3PH]BF4 in N,N-dimethyl-formamide
T=100°C; Heck reaction; 4 h;
参考文献
Colbon, Paul; Barnard, Jonathan H.; Purdie, Mark; Mulholland, Keith; Kozhevnikov, Ivan; Xiao, Jianliang
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1395 - 1400
反应条件
1: aq. ZnCl2 / dioxane
2: Al2O3
3: tetrahydrofuran / 2 h / Heating
4: HOAc / 2 h / Heating
5: 90 percent / cyclohexane; diethyl ether; tetrahydrofuran / 18 h / -78 - 20 °C
6: 50 percent / TsOH / diethyl ether / 20 °C
View Scheme
参考文献
Csaky, Aurelio G.; Contreras, Claudia; Mba, Myriam; Plumet, Joaquin
Synlett, 2002 , # 9 p. 1451 - 1454
