1,2,3,4-四氢-3-异喹啉羧酸 盐酸盐合成路线 （共 10 条）
反应条件
hydrogenchloride in water 4.5 h; Reflux;
参考文献
Chaniyara, Ravi; Kapuriya, Naval; Dong, Huajin; Lee, Pei-Chih; Suman, Sharda; Marvania, Bhavin; Chou, Ting-Chao; Lee, Te-Chang; Kakadiya, Rajesh; Shah, Anamik; Su, Tsann-Long
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 275 - 286
参考文献
Eli Lilly and Company
Patent: US5508407 A1, 1996 ;
反应条件
1: 99 percent / NaOH / 2-methyl-propan-2-ol; various solvent(s) / 12 h / 20 °C 2: 98 percent / borane-THF complex / tetrahydrofuran / 0 - 20 °C 3: 90 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.83 h / -78 - 0 °C View Scheme
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
反应条件
hydrogenchloride 72 h; Heating;
参考文献
Grunewald, Gary L.; Sall, Daniel J.; Monn, James A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 824 - 830
反应条件
sodium hydroxide in acetone T=20°C; 1 h;
参考文献
Grunewald, Gary L.; Romero, F. Anthony; Criscione, Kevin R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 134 - 140
反应条件
1: 99 percent / NaOH / 2-methyl-propan-2-ol; various solvent(s) / 12 h / 20 °C 2: 98 percent / borane-THF complex / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
反应条件
sodium hydroxide in tert-butyl alcohol T=20°C; 12 h;
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
反应条件
1: 10.7 g / HCl / 72 h / Heating 2: 99 percent / H4NOH / 16 h / Ambient temperature View Scheme
参考文献
Grunewald, Gary L.; Sall, Daniel J.; Monn, James A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 824 - 830
反应条件
acetic anhydride
Heating;
参考文献
Anderson, Wayne K.; McPherson, Howard L.; New, James S.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 513 - 517
反应条件
1: L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride With sodium hydroxide in acetone
T=20°C;
2: benzoyl chloride With sodium hydroxide in acetone
T=20°C; pH=> 10;
3: With hydrogenchloride in water
pH=5 - 6;
参考文献
Chaniyara, Ravi; Kapuriya, Naval; Dong, Huajin; Lee, Pei-Chih; Suman, Sharda; Marvania, Bhavin; Chou, Ting-Chao; Lee, Te-Chang; Kakadiya, Rajesh; Shah, Anamik; Su, Tsann-Long
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 275 - 286
