3,4-吡咯二羧酸二乙酯合成路线 （共 15 条）
反应条件
1: aqueous KOH 2: diethyl ether View Scheme
参考文献
Nicolaus; Mangoni
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 358,368
参考文献
Nicolaus; Mangoni
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 358,368
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20 - 45°C; 2: With sodium sulfate in tetrahydrofuran; diethyl ether 0.5 h; 3: With ammonium chloride in tetrahydrofuran; diethyl ether; water 0.25 h;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
potassium tert-butylate in tetrahydrofuran
T=0 - 25°C; 2.33 h; Inert atmosphere;
参考文献
De Assis, Francisco F.; De Souza, Juliana M.; Assis, Beatriz H.K.; Brocksom, Timothy J.; De Oliveira, Kleber T.
Dyes and Pigments, 2013 , vol. 98, # 1 p. 153 - 159
反应条件
ammonium acetate in ethanol
24 h; Heating;
参考文献
Kaesler, Ralph W.; LeGoff, Eugene
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4399 - 4402
反应条件
1: 63 percent / 5 h / 160 °C
2: 97 percent / ammonium acetate / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Kaesler, Ralph W.; LeGoff, Eugene
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4399 - 4402
反应条件
1: TFA / acetonitrile / 15 h / 20 °C
2: aq. NaOH / acetonitrile / 0.5 h / 20 °C
View Scheme
参考文献
Bergauer; Gmeiner
Synthesis, 2001 , # 15 p. 2281 - 2288
反应条件
diethyl ether; ammonia
Erwaermen des Reaktionsprodukts mit konz. H2SO4 auf 45grad;
参考文献
Kornfeld; Jones
Journal of Organic Chemistry, 1954 , vol. 19, p. 1671,1677
反应条件
1: sodium ethylate; diethyl ether
2: diethyl ether; ethanolic NH3 / Erwaermen des Reaktionsprodukts mit konz. H2SO4 auf 45grad
View Scheme
参考文献
Kornfeld; Jones
Journal of Organic Chemistry, 1954 , vol. 19, p. 1671,1677
反应条件
1: ethanol; sulfuric acid
2: sodium ethylate; diethyl ether
3: diethyl ether; ethanolic NH3 / Erwaermen des Reaktionsprodukts mit konz. H2SO4 auf 45grad
View Scheme
参考文献
Kornfeld; Jones
Journal of Organic Chemistry, 1954 , vol. 19, p. 1671,1677
