(1R,5S,6R)-6-(羟基甲基)-3-氮杂双环[3.1.0]己烷-3-羧酸叔丁酯合成路线 （共 11 条）
反应条件
in dichloromethane; ethyl acetate
参考文献
US2002/94989 A1, ;
US 20020094989 A1
反应条件
triethylamine in dichloromethane T=20°C; 18 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 11 p. 2974 - 2976
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 16 p. 4741 - 4744
反应条件
1.1: triethylamine / acetone / 3 h / 20 °C / Large scale reaction 1.2: 1 h / Reflux; Large scale reaction 2.1: sulfuric acid / 6 h / 60 °C / Large scale reaction 3.1: 15 - 30 °C 4.1: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1.1: acetic anhydride / acetic acid / 2 h / Reflux; Large scale reaction 2.1: triethylamine / acetone / 3 h / 20 °C / Large scale reaction 2.2: 1 h / Reflux; Large scale reaction 3.1: sulfuric acid / 6 h / 60 °C / Large scale reaction 4.1: 15 - 30 °C 5.1: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1.1: sodium hydroxide / ethanol / 50 °C / Reflux; Large scale reaction 2.1: acetic anhydride / acetic acid / 2 h / Reflux; Large scale reaction 3.1: triethylamine / acetone / 3 h / 20 °C / Large scale reaction 3.2: 1 h / Reflux; Large scale reaction 4.1: sulfuric acid / 6 h / 60 °C / Large scale reaction 5.1: 15 - 30 °C 6.1: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1: sulfuric acid / 6 h / 60 °C / Large scale reaction 2: 15 - 30 °C 3: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1: 180 °C / open vessel 2: 15 - 30 °C 3: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1: 15 - 30 °C 2: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
