5-(2-溴-乙酰基)-噻吩-2-羧酸甲酯合成路线 （共 6 条）
反应条件
copper(ll) bromide in ethyl acetate
6 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/79791 A1, 2005 ;
Location in patent: Page/Page column 126-127 ;
WO 2005/079791 A1
反应条件
1: 88 percent / Na2CO3 / dimethylformamide / Ambient temperature
2: 73 percent / Jones reagent / acetone / 1 h / Ambient temperature
3: SOCl2 / 1.5 h / Heating
4: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min
View Scheme
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
1: 73 percent / Jones reagent / acetone / 1 h / Ambient temperature
2: SOCl2 / 1.5 h / Heating
3: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min
View Scheme
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
1: SOCl2 / 1.5 h / Heating
2: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min
View Scheme
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
hydrogen bromide
1) ether, 0 deg C, overnight, 2) 20 min; Yield given. Multistep reaction;
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
1: (i) EtOH, (ii) aq. NaOH
2: Br2 / CHCl3
3: aq. HCl
4: CHCl3 / Heating
View Scheme
参考文献
Godovikova,S.N.; Gol'dfarb,Ya.L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1965 , p. 1391 - 1397
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1965 , p. 1434 - 1441
