4 - (吡啶- 3 -基)-4-氧代丁酸盐酸盐合成路线 （共 10 条）
反应条件
sulfuric acid; water 3 h; Heating / reflux;
参考文献
Bourguignon, Jean-Jacques; Maitre, Michel; Klotz, Evelyne; Schmitt, Martine; Gobaille, Serge; Macher, Jean-Paul
Patent: US2005/113366 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
1: acetic acid; hydrogen bromide 2: malonic acid diethyl ester / Erhitzen der Reaktionsloesung mit wss. HCl View Scheme
参考文献
Wingfield
Journal of Organic Chemistry, 1959 , vol. 24, p. 872
反应条件
diethyl malonate Erhitzen der Reaktionsloesung mit wss. HCl;
参考文献
Wingfield
Journal of Organic Chemistry, 1959 , vol. 24, p. 872
反应条件
phosphate buffer T=25°C; pH=6.5; 240 h;
参考文献
Forzato, Cristina; Furlan, Giada; Nitti, Patrizia; Pitacco, Giuliana; Valentin, Ennio; Zangrando, Ennio; Buzzini, Pietro; Goretti, Marta; Turchetti, Benedetta
Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2026 - 2036
反应条件
1: NaNH2; diethyl ether 2: aqueous H2SO4 View Scheme
参考文献
Castle; Burger
Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 163
反应条件
1: potassium ethylate; ethanol 2: aqueous HCl View Scheme
参考文献
Sugasawa et al.
Pharmaceutical Bulletin, 1954 , vol. 2, p. 39
参考文献
Zymalkowski; Trenktrog
Archiv der Pharmazie (Weinheim, Germany), 1959 , vol. 292, p. 9,13
Full Text Show Details
Sugasawa et al.
Pharmaceutical Bulletin, 1954 , vol. 2, p. 39
Full Text View citing articles Show Details
Olin Mathieson Chem. Corp.
Patent: US2727899 , 1953 ;
反应条件
ethanol; ammonia; nickel T=130°C; P=58840.6 Torr; Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 81, p. 3951,3954
反应条件
sodium hydroxide; sodium tetrahydroborate
参考文献
Michel; Zymalkowski
Archiv der Pharmazie, 1974 , vol. 307, # 9 p. 689 - 694
反应条件
1: ethanolic HCl
2: amalgamated zinc; aqueous HCl / Erwaermen des Reaktionsprodukts mit aethanol. HCl
View Scheme
参考文献
Olin Mathieson Chem. Corp.
Patent: US2727899 , 1953 ;
