3-甲基-4-膦酰丁烯酸三乙酯合成路线 （共 23 条）
反应条件
1: NaH / tetrahydrofuran 2: Dibal-H / diethyl ether 3: n-Bu4NF / tetrahydrofuran 4: MnO2 View Scheme
参考文献
Borhan; Kunz; Wang; Nakanishi
Journal of the American Chemical Society, 1997 , vol. 119, # 24 p. 5758 - 5759
反应条件
1.1: N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / 0 °C / Horner-Wadsworth-Emmons reaction 1.2: -78 - 0 °C 2.1: water; sodium hydroxide / methanol; dimethyl sulfoxide / 2 h / 65 °C 2.2: 0 °C / pH 5 View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
potassium hydroxide; lithium aluminium tetrahydride; sodium hydride Yield given. Multistep reaction;
参考文献
Boehm, Marcus F.; McClurg, Michael R.; Pathirana, Charles; Mangelsdorf, David; White, Steven K.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 408 - 414
反应条件
potassium hydroxide; lithium aluminium tetrahydride; sodium hydride Yield given. Multistep reaction;
参考文献
Boehm, Marcus F.; McClurg, Michael R.; Pathirana, Charles; Mangelsdorf, David; White, Steven K.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 408 - 414
反应条件
potassium hydroxide; lithium aluminium tetrahydride; sodium hydride Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 3 p. 408 - 414
反应条件
1.1: N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / 0 °C / Horner-Wadsworth-Emmons reaction
1.2: -78 - 0 °C
2.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 1 h / 0 - 25 °C
3.1: manganese(IV) oxide; sodium carbonate / dichloromethane / 1 h / 25 °C
View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
sodium hydride in ethylene glycol dimethyl ether
参考文献
Streinz, Ludvik; Romanuk, Miroslav
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 9 p. 2531 - 2535
反应条件
1: 16 percent / 50percent suspension of sodium hydride in oil / 1,2-dimethoxy-ethane
2: 67 percent / boron trifluoride etherate - mercuric oxide complex / 0 deg C, 30 min; then room temperature, 15 min
View Scheme
参考文献
Streinz, Ludvik; Romanuk, Miroslav
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 9 p. 2531 - 2535
反应条件
1: 16 percent / 50percent suspension of sodium hydride in oil / 1,2-dimethoxy-ethane
2: 67 percent / boron trifluoride etherate - mercuric oxide complex / 0 deg C, 30 min; then room temperature, 15 min
3: 84.5 percent / p-toluenesulfonic acid / acetone / 0.5 h / 80 - 90 °C
View Scheme
参考文献
Streinz, Ludvik; Romanuk, Miroslav
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 9 p. 2531 - 2535
反应条件
1: 16 percent / 50percent suspension of sodium hydride in oil / 1,2-dimethoxy-ethane
2: 67 percent / boron trifluoride etherate - mercuric oxide complex / 0 deg C, 30 min; then room temperature, 15 min
3: 84.5 percent / p-toluenesulfonic acid / acetone / 0.5 h / 80 - 90 °C
4: 96 percent / tetramethylammonium borohydride / methanol / 0 °C
View Scheme
参考文献
Streinz, Ludvik; Romanuk, Miroslav
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 9 p. 2531 - 2535
