3-甲基-4-膦酰丁烯酸三乙酯合成路线 （共 23 条）
反应条件
T=165 - 170°C; 0.0833333 h;
参考文献
Mata, Ernesto G.; Thomas, Eric J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 7 p. 785 - 800
反应条件
1: N-bromosuccinimide, azobisisobutylnitrile / CCl4 / 3 h / Heating 2: 85.6 percent / 1.) 120 deg C, 30 min, 2.) reflux, 2 h View Scheme
参考文献
The Wellcome Foundation Limited
Patent: US5162367 A1, 1992 ;
反应条件
triethyl phosphite; dibenzoyl peroxide in benzene
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP251472 B1, 1991 ;
参考文献
Ivanova, Diana; Gronemeyer, Hinrich; deLera, Angel R.
ChemMedChem, 2011 , vol. 6, # 8 p. 1518 - 1529
反应条件
1: carbon tetrabromide; triphenylphosphine / acetonitrile / 1 h / 25 °C 2: 100 - 150 °C / Neat (no solvent) View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
1: tetrachloromethane; triphenylphosphine / acetonitrile / 1 h / 25 °C 2: 2.5 h / 150 °C View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
N-bromosuccinmide 1.) CCl4; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bergdahl, Mikael; Hett, Robert; Friebe, Timothy L.; Gangloff, Anthony R.; Iqbal, Javed; et al.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7371 - 7374
反应条件
T=150°C; Michaelis-Arbuzov reaction; 2.5 h; optical yield given as percent de;
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
参考文献
Ajami; Crouse
1975 , vol. 11, # 1 p. 117 - 126
反应条件
Arbuzov reaction; 4 h; Reflux;
参考文献
Ivanova, Diana; Gronemeyer, Hinrich; deLera, Angel R.
ChemMedChem, 2011 , vol. 6, # 8 p. 1518 - 1529
