1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
1: acetone; CrO3; aqueous H2SO4 / 5 °C View Scheme
参考文献
Bowden; Jones
Journal of the Chemical Society, 1946 , p. 52
反应条件
sodium hydride; sodium iodide in ethylene glycol dimethyl ether T=20°C; 5 h;
参考文献
Trost, Barry M.; Toste, F. Dean
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5025 - 5036
反应条件
1: CuI; Et3N / (Ph3P)2PdCl2 / 24 h / 20 °C 2: LiCl; K2CO3 / Pd(OAc)2 / dimethylformamide / 16 h / 100 °C View Scheme
参考文献
Mahanty, Jyan S.; De, Mahuya; Das, Palas; Kundu, Nitya G.
Tetrahedron, 1997 , vol. 53, # 39 p. 13397 - 13418
反应条件
potassium hydroxide in ethanol 24 h; Ambient temperature;
参考文献
Moehrle, Hans; Platzek, Thomas; Wille, Romanus; Wendisch, Detlef
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1985 , vol. 40, # 4 p. 524 - 533
反应条件
ueber das Cinchonin-Salz des 2-Carboxy-3-nitro-benzoyl-Derivats;
参考文献
Waldinger, Claudia; Schneider, Manfred; Botta, Maurizio; Corelli, Federico; Summa, Vincenzo
Tetrahedron Asymmetry, 1996 , vol. 7, # 5 p. 1485 - 1488
反应条件
ChiroCLEC-PC; water in toluene Acetylation; enzymatic resolution; 6.5 h; Enzymatic reaction; Product distribution; Further Variations:reaction time;
参考文献
Chen, Peiran; Zhu, Xiyin
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 184 - 188
反应条件
1: acetyl chloride With 1,4-diaza-bicyclo[2.2.2]octane; (S)-3,3'-bis-(2,4,6-triisopropylphenyl)-BINOL phosphoric acid in diethyl ether T=20°C; 0.0833333 h; Inert atmosphereResolution of racemate; 2: 3-hydroxy-3-phenyl-prop-1-yne in diethyl ether T=-20°C; 5 h; Resolution of racemateInert atmosphere; optical yield given as percent ee;
参考文献
Mandai, Hiroki; Murota, Kyouta; Mitsudo, Koichi; Suga, Seiji
Organic Letters, 2012 , vol. 14, # 13 p. 3486 - 3489
反应条件
(S)-N-(1-(tert-butylcarbamoyl)-1-(4-(dimethylamino)pyridin-3-yl)methyl)-L-valinemethyl ester; triethylamine in toluene T=-78°C; 15 h; enantioselective reaction;
参考文献
Mandai, Hiroki; Irie, Shunsuke; Akehi, Masaru; Yuri, Kazunobu; Yoden, Masaaki; Mitsudo, Koichi; Suga, Seiji
Heterocycles, 2013 , vol. 87, # 2 p. 329 - 340
反应条件
tetraproline chiral stationary phase packed on HPLC column in hexane; isopropyl alcohol Resolution of racemate;
参考文献
Dai, Zhi; Ye, Guozhong; Pittman Jr., Charles U.; Li, Tingyu
Chirality, 2012 , vol. 24, # 4 p. 329 - 338
反应条件
novozyme 435 in benzene T=32°C; 0.333333 h; Product distribution; Further Variations:Solventstime;
参考文献
Raminelli, Cristiano; Comasseto, Joao V.; Andrade, Leandro H.; Porto, Andre L.M.
Tetrahedron Asymmetry, 2004 , vol. 15, # 19 p. 3117 - 31722
