(S)-4-硝基-Alpha-甲基苄胺合成路线 （共 16 条）
反应条件
1: With borane-THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester in tetrahydrofuran T=0 - 5°C; 48 h; 2: With hydrogenchloride in tetrahydrofuran
参考文献
Chu, Yunbo; Shan, Zixing; Liu, Dejun; Sun, Nannan
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3998 - 4001
反应条件
formate dehydrogenase; Arthrobacter citreus S9 ω-transaminase; ATA-113 ω-transaminase; sodium formate; isopropylamine; Reduced nicotinamide-adenine dinucleotide; yeast alcohol dehydrogenase pH=7; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Cassimjee, Karim Engelmark; Branneby, Cecilia; Abedi, Vahak; Wells, Andrew; Berglund, Per
Chemical Communications, 2010 , vol. 46, # 30 p. 5569 - 5571
反应条件
borane-THF; C19H23BNO3(1-)*H(1+) in tetrahydrofuran; 1,4-dioxane T=0°C; Inert atmosphere; enantioselective reaction;
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1: With trifluorormethanesulfonic acid; nitric acid in dichloromethane T=-78 - -40°C; 17.5 h; Inert atmosphere; 2: With potassium carbonate in methanol; water 16 h; Reflux;
参考文献
Fowler, Sarah A.; Luechapanichkul, Rinrada; Blackwell, Helen E.
Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1440 - 1449
反应条件
1: H2 / <(COD)Rh(1,2-bis((2R,5R)-2,5-diethylphospholano)-benzene)>+CF3SO3- / propan-2-ol / 12 h / 0 °C / 3102.9 Torr 2: samarium(II) iodide / methanol; tetrahydrofuran / 0.5 h View Scheme
参考文献
Burk, Mark J.; Martinez, Jose P.; Feaster, John E.; Cosford, Nick
Tetrahedron, 1994 , vol. 50, # 15 p. 4399 - 4428
反应条件
1.1: NaH / dimethylformamide / 0 °C 1.2: 75 percent / dimethylformamide / 0 - 20 °C 2.1: BH3*THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester / tetrahydrofuran / 48 h / 0 - 5 °C 2.2: aq. HCl / tetrahydrofuran View Scheme
参考文献
Chu, Yunbo; Shan, Zixing; Liu, Dejun; Sun, Nannan
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3998 - 4001
反应条件
1: With ammonium acetate; sodium cyanoborohydride in methanol T=20°C; reductive amination; 2: racemate resolution; Further stages. Title compound not separated from byproducts.;
参考文献
Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1339 - 1347
反应条件
samarium diiodide in tetrahydrofuran; methanol 0.5 h;
参考文献
Burk, Mark J.; Martinez, Jose P.; Feaster, John E.; Cosford, Nick
Tetrahedron, 1994 , vol. 50, # 15 p. 4399 - 4428
反应条件
(i) (nitration), (ii) (hydrolysis); Multistep reaction;
参考文献
Cope,A.C. et al.
Journal of the American Chemical Society, 1970 , vol. 92, # 5 p. 1243 - 1247
反应条件
1: With (S)-isopropylidene glycerol 3-carboxy-2-naphthoate in methanol 0.166667 h; Heating; 2: With sulfuric acid in ethyl acetate
参考文献
Pallavicini, Marco; Bolchi, Cristiano; Fumagalli, Laura; Valoti, Ermanno; Villa, Luigi
Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2277 - 2282
