3-(4-氟苯基)-1-苯基-1-丙酮合成路线 （共 10 条）
反应条件
caesium carbonate in toluene
T=115°C; 48 h; Inert atmosphere;
参考文献
Shimizu, Ken-ichi; Sato, Ryosuke; Satsuma, Atsushi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 3982 - 3986
Angewandte Chemie, 2009 , vol. 121, p. 4042 - 4046
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; silica gel in toluene
T=70°C; 17 h; Inert atmosphereDarkness;
参考文献
Stroba, Adriana; Schaeffer, Francis; Hindie, Valerie; Lopez-Garcia, Laura; Adrian, Iris; Froehner, Wolfgang; Hartmann, Rolf W.; Biondi, Ricardo M.; Engel, Matthias
Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4683 - 4693
反应条件
potassium phosphate; Wilkinson's catalyst; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in 1,4-dioxane
T=60°C; P=750.075 Torr; 20 h; Inert atmosphere;
参考文献
Jiang, Quanbin; Guo, Tenglong; Wang, Qingfu; Wu, Ping; Yu, Zhengkun
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 9 p. 1874 - 1880
反应条件
potassium carbonate
0.0833333 h; Microwave irradiationSonicationReflux;
参考文献
Feng, Huangdi; Li, Yuan; Van Der Eycken, Erik V.; Peng, Yanqing; Song, Gonghua
Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1160 - 1162
反应条件
potassium phosphate in toluene
T=110°C; 12 h; Inert atmosphere;
参考文献
Jang, Jum Suk; Kwon, Min Serk; Kim, Hyun Gyu; Park, Jae Wook; Lee, Jae Sung
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 5 p. 1617 - 1621
反应条件
1: sodium hydroxide / ethanol / 4 h / 0 - 20 °C
2: acetoxy(2,6-bis((diphenylphosphino)methyl)-3,5-dimethylphenyl)palladium(II); butan-1-ol; potassium carbonate / 1 h / |Reflux
View Scheme
参考文献
Ding, Boqiang; Zhang, Zhenfeng; Liu, Yangang; Sugiya, Masashi; Imamoto, Tsuneo; Zhang, Wanbin
Organic Letters, 2013 , vol. 15, # 14 p. 3690 - 3693
反应条件
benzaldehyde; potassium hydroxide
T=130°C; 48 h; Schlenk techniqueInert atmosphereGreen chemistry;
参考文献
Xu, Qing; Chen, Jianhui; Liu, Quan
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 697 - 704
反应条件
1: oxygen / 2,3,4-trifluorotoluene / 6 h / 50 °C / 760.05 Torr
2: potassium phosphate / toluene / 12 h / 110 °C / Inert atmosphere
View Scheme
参考文献
Jang, Jum Suk; Kwon, Min Serk; Kim, Hyun Gyu; Park, Jae Wook; Lee, Jae Sung
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 5 p. 1617 - 1621
反应条件
1: sodium hydroxide / ethanol; water / 20 °C
2: potassium carbonate / 0.08 h / Microwave irradiation; Sonication; Reflux
View Scheme
参考文献
Feng, Huangdi; Li, Yuan; Van Der Eycken, Erik V.; Peng, Yanqing; Song, Gonghua
Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1160 - 1162
反应条件
sodium hydroxide
T=130°C; 24 h; Sealed tubeSchlenk techniqueInert atmosphere; Overall yield = 56 percent;
参考文献
Xu, Qing; Chen, Jianhui; Tian, Haiwen; Yuan, Xueqin; Li, Shuangyan; Zhou, Chongkuan; Liu, Jianping
Angewandte Chemie - International Edition, 2014 , vol. 53, # 1 p. 225 - 229
Angew. Chem., 2014 , vol. 126, # 1 p. 229 - 233,5
