1: 57 percent / NaH / tetrahydrofuran / 2.5 h / 20 - 60 °C 2: 83 percent / 4-(dimethylamino)pyridine, triethylamine / CH2Cl2 3: tetrahydrofuran; diethyl ether / 1 h / 0 °C 4: 64 percent / EtSH, n-BuLi / tetrahydrofuran; dimethylformamide / 2.5 h / 80 °C 5: 23 percent / methanesulfonic acid / 72 h / Ambient temperature 6: 82 percent / K2CO3 / dimethylformamide / 1 h / Heating 7: 74 percent / AlCl3, EtSH / 1,2-dichloro-ethane / 2.5 h / 0 °C View Scheme
参考文献
Jones, Charles D.; Blaszczak, Larry C.; Goettel, Mary E.; Suarez, Tulio; Crowell, Thomas A.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 931 - 938
