1-氯甲酰基-3-甲磺酰基-2-咪唑烷酮合成路线 （共 5 条）
参考文献
Bayer Aktiengesellschaft
Patent: US3972870 A1, 1976 ;
反应条件
pyridine in chloroform T=50 - 55°C; Addition; 3 h;
参考文献
Su, Weike; Huang, Kewei; Zhang, Yongmin
Organic Preparations and Procedures International, 2000 , vol. 32, # 5 p. 498 - 501
反应条件
in chloroform T=55 - 60°C; chloroformylation; 3 h;
参考文献
Su; Zhang
Journal of Chemical Research - Part S, 2000 , # 9 p. 440 - 441
反应条件
sodium hydroxide in water 3 h;
参考文献
Koenig, H.-B.; Metzger, K. G.; Offe, H.-A.; Schroeck, W.
Arzneimittel Forschung, 1983 , vol. 33, # 1 p. 88 - 90
反应条件
1: 56 percent / 2 N NaOH / dioxane; H2O / pH = 7.5
2: 1.) N-methylmorpholine / tetramethylchloroformamidinium chloride; 2.) N-methylmorpholine / 1.) CH2Cl2, THF, -40 deg C, 5 min; 2.) THF, H2O, pH = 2.5, 30 min
View Scheme
参考文献
Koenig, H.-B.; Metzger, K. G.; Offe, H.-A.; Schroeck, W.
Arzneimittel Forschung, 1983 , vol. 33, # 1 p. 88 - 90
