6-氨基-1,3-二乙基-2,4(1H,3H)-嘧啶二酮合成路线 （共 11 条）
反应条件
1: With acetic anhydride T=60°C; 0.166667 h; microwave irradiation; 2: With sodium hydroxide in ethanol T=20°C;
参考文献
Devi, Ipsita; Bhuyan, Pulak J.
Tetrahedron Letters, 2005 , vol. 46, # 34 p. 5727 - 5729
反应条件
in acetic acid T=80°C; 2 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
acetic anhydride T=60°C; Behandeln des entstandenen N.N'-Diaethyl-N-cyanacetyl-harnstoffs mit Natronlauge;
参考文献
Scarlat
Chem. Zentralbl., 1904 , vol. 75, # II p. 1497
反应条件
1: POCl3 / CHCl3; dimethylformamide / 1.67 h 2: CHCl3 / 4.5 h / Heating 3: 1percent NaHCO3 / 6 h / Heating 4: 340 °C View Scheme
参考文献
Rodgers, Gary R.; Neish, William J. P.
Monatshefte fuer Chemie, 1986 , vol. 117, p. 879 - 882
反应条件
1: With nitric acid; acetic acid in water 2: With sodium dithionite; ammonia in water Further stages.;
参考文献
Labeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4155 - 4157
反应条件
sodium ethanolate in ethanol 1 h; Heating;
参考文献
Hirota, Kosaku; Kitade, Yukio; Senda, Shigeo
Heterocycles, 1980 , vol. 14, # 4 p. 407 - 410
反应条件
sodium nitrite in acetic acid T=50 - 60°C; 0.25 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 74 percent / acetic acid; NaNO2 / H2O / 0.25 h / 50 - 60 °C 2: 80 percent / NH3; sodium dithionite / H2O / 60 °C 3: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 4: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 74 percent / acetic acid; NaNO2 / H2O / 0.25 h / 50 - 60 °C 2: 80 percent / NH3; sodium dithionite / H2O / 60 °C 3: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 4: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C 5: 95 percent / potassium carbonate / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
thionyl chloride in ice-water; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US3959280 A1, 1976 ;
US 3959280 A
