2-氯噻唑-4-甲酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water T=20°C; 2.16667 h; Cooling with salt-ice;
参考文献
PHARMAGENE LABORATORIES LIMITED
Patent: WO2005/80367 A1, 2005 ;
Location in patent: Page/Page column 109 ;
反应条件
1: ethanol / 1.5 h / 105 °C / Inert atmosphere 2: tert.-butylnitrite; copper dichloride / acetonitrile / 1 h / 65 °C / Inert atmosphere View Scheme
参考文献
Ehmke, Veronika; Quinsaat, Jose Enrico Q.; Rivera-Fuentes, Pablo; Heindl, Cornelia; Freymond, Celine; Rottmann, Matthias; Brun, Reto; Schirmeister, Tanja; Diederich, Francois
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5764 - 5768
反应条件
1.1: N-bromosuccinmide / water; 1,4-dioxane / 1 h / -10 - 20 °C 1.2: 1 h / 80 °C 1.3: 0.17 h / 20 °C 2.1: tert.-butylnitrite; copper dichloride / tetrahydrofuran; acetonitrile / 23 - 65 °C View Scheme
参考文献
HANGZHOU BENSHENG PHARACEUTICALS CO., LTD.; Xu, Rongzhen; Xie, Fuwen; Lai, Hongxi; Rong, Frank
Patent: US2013/178470 A1, 2013 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide in dimethyl sulfoxide T=80°C; 16 h;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2007/14290 A2, 2007 ;
Location in patent: Page/Page column 91 ;
反应条件
1: With water; potassium hydroxide in ethanol T=0 - 20°C; 2: With hydrogenchloride in water T=20°C; pH=5.5; 72 h;
参考文献
BASF SE; Le VEZOUET, Ronan; SOeRGEL, Sebastian; DEFIEBER, Christian; GROss, Steffen; KOeRBER, Karsten; CULBERTSON, Deborah, L.; ANSPAUGH, Douglas, D.
Patent: WO2011/3796 A1, 2011 ;
Location in patent: Page/Page column 126; 127 ;
反应条件
triethylamine in N-methyl-acetamide
参考文献
Sankyo Company Limited
Patent: US4933355 A1, 1990 ;
反应条件
water; sodium hydroxide in ethanol T=20°C;
参考文献
HANGZHOU BENSHENG PHARACEUTICALS CO., LTD.; Xu, Rongzhen; Xie, Fuwen; Lai, Hongxi; Rong, Frank
Patent: US2013/178470 A1, 2013 ;
Location in patent: Paragraph 0107 ;
反应条件
in dimethyl sulfoxide
T=85°C; 16 h;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 46-47 ;
WO 2007/000582 A1
反应条件
ammonia in water
3 h;
参考文献
Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao
Patent: US2010/87448 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With sodium tetrahydroborate; ethanol
T=0 - 20°C;
2: With hydrogenchloride in water
pH=5;
参考文献
Biota Scientific Management Pty Ltd.
Patent: US7078403 B1, 2006 ;
Location in patent: Page/Page column 25 ;
