3,5-二氯-4-甲氧基苯甲酸合成路线 （共 6 条）
反应条件
4 A molecular sieve; pyridinium chlorochromate in dichloromethane T=20°C; 1 h;
参考文献
Kousaka, Takeshi; Mori, Kenji
Bioscience, Biotechnology and Biochemistry, 2002 , vol. 66, # 3 p. 697 - 701
反应条件
1: 3,5-dichloro-4-hydroxy-benzaldehyde With potassium carbonate in acetone T=20°C; 0.5 h; 2: methyl iodide in acetone T=20°C; Reflux;
参考文献
EXONHIT S.A.; LEBLOND, Bertrand; TAVERNE, Thierry; BEAUSOLEIL, Eric; CHAUVIGNAC, Cedric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent
Patent: WO2011/151423 A1, 2011 ;
Location in patent: Page/Page column 175-176 ;
反应条件
sulfuryl dichloride 72 h; Heating;
参考文献
Kamiya; Murata; Yamabe
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 7 p. 1740 - 1744
反应条件
1: 99 percent / LiAlH4 / diethyl ether / 1 h / 20 °C 2: 97 percent / PCC; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Xu, Xiang D.; Koszyk, Francis J.; Collins, Paul W.; Koboldt, Carol M.; Veenhuizen, Amy W.; Perkins, William E.; Casier, Jacquelen J.; Masferrer, Jaime L.; Zhang, Yan Y.; Gregory, Susan A.; Seibert, Karen; Isakson, Peter C.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1634 - 1647
参考文献
Durrans
Journal of the Chemical Society, 1923 , vol. 123, p. 1427
反应条件
pyridine; hydroxylamine hydrochloride 1.) RT, 15 min, 2.) toluene, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Xu, Xiang D.; Koszyk, Francis J.; Collins, Paul W.; Koboldt, Carol M.; Veenhuizen, Amy W.; Perkins, William E.; Casier, Jacquelen J.; Masferrer, Jaime L.; Zhang, Yan Y.; Gregory, Susan A.; Seibert, Karen; Isakson, Peter C.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1634 - 1647
