(R)-(-)-2-甲基吡咯烷合成路线 （共 14 条）
反应条件
sodium hydroxide in water
参考文献
Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.
Patent: US2005/256309 A1, 2005 ;
Location in patent: Page/Page column 31 ;
US 20050256309 A1
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=20°C; Hydrogenolysis; P=6840.46 Torr;
参考文献
Andres, Jose M.; Herraiz-Sierra, Ignacio; Pedrosa, Rafael; Perez-Encabo, Alfonso
European Journal of Organic Chemistry, 2000 , # 9 p. 1719 - 1726
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=20°C; 0.5 h; Inert atmosphere;
参考文献
Reddy, Leleti Rajender; Das, Sonia G.; Liu, Yugang; Prashad, Mahavir
Journal of Organic Chemistry, 2010 , vol. 75, # 7 p. 2236 - 2246
反应条件
Me2SiCp''((R,S)-neomenthylCp)NdCH(TMS)2 in pentane T=0°C; Title compound not separated from byproducts;
参考文献
Giardello, Michael A.; Conticello, Vincent P.; Brard, Laurent; Gagne, Michel R.; Marks, Tobin J.
Journal of the American Chemical Society, 1994 , vol. 116, # 22 p. 10241 - 10254
反应条件
1: 81 percent / LiAlH4 / diethyl ether / Heating 2: Yttrium(III) bis(thiolato) chiral complex / benzene-d6 / 8 h / 60 °C View Scheme
参考文献
Joon, Young Kim; Livinghouse, Tom
Organic Letters, 2005 , vol. 7, # 9 p. 1737 - 1739
反应条件
hydrogen; platinum(IV) oxide in acetic acid 24 h; Yield given. Yields of byproduct given;
参考文献
Kuil, Lucia A. van de; Veldhuizen, Yvonne S. J.; Grove, David M.; Zwikker, Jan W.; Jenneskens, Leonardus W.; et al.
Recueil des Travaux Chimiques des Pays-Bas, 1994 , vol. 113, # 5 p. 267 - 277
反应条件
5 Pd(II)/C(eggshell); ammonium formate in methanol; water T=70°C; 0.0833333 h; Inert atmosphere;
参考文献
Shen, Xiaoqiang; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 3 p. 564 - 567
反应条件
whole cells of Streptomyces sp. GF3585 T=25°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Mitsukura, Koichi; Suzuki, Mai; Tada, Kazuhiro; Yoshida, Toyokazu; Nagasawa, Toru
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4533 - 4535
反应条件
sodium in 3-methyl-1-butanol Inert atmosphere;
参考文献
Denmark, Scott E.; Edwards, James P.; Weber, Theodor; Piotrowski, David W.
Tetrahedron Asymmetry, 2010 , vol. 21, # 9-10 p. 1278 - 1302
反应条件
lithium aluminium tetrahydride in diethyl ether 1.) reflux, 2.5 h, 2.) r.t., 16 h; Yield given. Yields of byproduct given;
参考文献
Kuil, Lucia A. van de; Veldhuizen, Yvonne S. J.; Grove, David M.; Zwikker, Jan W.; Jenneskens, Leonardus W.; et al.
Recueil des Travaux Chimiques des Pays-Bas, 1994 , vol. 113, # 5 p. 267 - 277
