Alpha-溴代-N-(2,6-二甲基苯基)丙酰胺合成路线 （共 5 条）
反应条件
in dichloromethane 0.5 h; Heating;
参考文献
Lebedeva, A. S.; Chernyakova, I. V.; Likhosherstov, A. M.; Sipilina, N. M.; Ivanova, T. I.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 2 p. 79 - 83
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 2 p. 13 - 15
反应条件
sodium acetate; acetic acid
参考文献
Loefgren; Lundquist
Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 206,211
反应条件
1: 89 percent / dimethylformamide / 2 h / Heating 2: 1.) N2H4*H2O, 2.) conc. HCl / 1.) aq. EtOH, reflux, 2.) aq. EtOH, reflux, 30 min View Scheme
参考文献
Astra Pharmaceutical Products, Inc.
Patent: US4218477 A1, 1980 ;
US 4218477 A
反应条件
hydrogenchloride in toluene
参考文献
Astra Pharmaceutical Products, Inc.
Patent: US4022899 A1, 1977 ;
参考文献
Loefgren; Lundquist
Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 206,211
