1,1-二甲酸乙酯环戊烷合成路线 （共 39 条）
反应条件
1: NaOH; H2O / 48 h / 20 °C 2: 44 percent / SF4 / 3 h / 30 °C View Scheme
参考文献
Dmowski, Wojciech; Wolniewicz, Adam
Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 141 - 146
反应条件
lithium aluminium tetrahydride
参考文献
Houk,J.; Whitesides,G.M.
Journal of the American Chemical Society, 1987 , vol. 109, p. 6825
反应条件
1: 65.7 percent / KOH / ethanol / Ambient temperature 2: 85.7 percent / SOCl2 / toluene / Heating 3: NaN3 / H2O; acetone / 0 °C 4: benzene / Heating 5: 77.8 percent / LiAlH4 / diethyl ether / Ambient temperature View Scheme
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere 2.1: triethylamine / dichloromethane / 0.5 h / |Inert atmosphere; |Cooling 2.2: -3 - 20 °C / |Inert atmosphere 3.1: N,N-dimethyl-formamide / 100 °C / |Inert atmosphere 4.1: water; sodium hydroxide / ethanol / |Inert atmosphere; |Reflux 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
BETA PHARMA CANADA INC; ASTAR BIOTECH LLC; WANG, Zhaoyin; LI, Lianhai
Patent: WO2013/185202 A1, 2013 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere 2.1: triethylamine / dichloromethane / 0.5 h / |Inert atmosphere; |Cooling 2.2: -3 - 20 °C / |Inert atmosphere 3.1: N,N-dimethyl-formamide / 100 °C / |Inert atmosphere 4.1: water; sodium hydroxide / ethanol / |Inert atmosphere; |Reflux View Scheme
参考文献
BETA PHARMA CANADA INC; ASTAR BIOTECH LLC; WANG, Zhaoyin; LI, Lianhai
Patent: WO2013/185202 A1, 2013 ;
反应条件
1: 65.7 percent / KOH / ethanol / Ambient temperature
2: 85.7 percent / SOCl2 / toluene / Heating
3: NaN3 / H2O; acetone / 0 °C
4: benzene / Heating
View Scheme
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
反应条件
1: 65.7 percent / KOH / ethanol / Ambient temperature
2: 85.7 percent / SOCl2 / toluene / Heating
View Scheme
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
反应条件
1: 65.7 percent / KOH / ethanol / Ambient temperature
2: 85.7 percent / SOCl2 / toluene / Heating
3: NaN3 / H2O; acetone / 0 °C
4: benzene / Heating
5: 77.8 percent / LiAlH4 / diethyl ether / Ambient temperature
6: 2.) NEt3 / 1.) 3 h, 0 deg C, ether, 2.) 20 h, r.t., ether
View Scheme
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
反应条件
sodium in ethanol
T=110°C; 7 h;
参考文献
Al-Ashmawi; Ghoneim; Khalifa
Pharmazie, 1980 , vol. 35, # 10 p. 591 - 593
反应条件
1: 79 percent / NaAlH2(OCH2OCH3)2 / tetrahydrofuran
2: 59 percent / pyridine
3: 83 percent / LiBr / 2-ethoxy-ethanol
View Scheme
参考文献
Schubert; Leahy
Journal of the American Chemical Society, 1957 , vol. 79, p. 381,384
