苯胺-2,3,4,5,6-d5合成路线 （共 28 条）
反应条件
triethylamine in dichloromethane 2 h; Ambient temperature;
参考文献
Neubert, Mary E.
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 129, p. 327 - 374
反应条件
1: 20 °C / Inert atmosphere; Cooling with ice 2: chlorosulfonic acid / 20 °C / Inert atmosphere; Cooling with ice 3: water; sodium hydroxide / 3 h / 95 °C View Scheme
参考文献
Shi, Lei; Chen, Liping; Chen, Ryan; Chen, Liqin
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 3 p. 148 - 152
反应条件
1: 94.1 percent / benzene / Heating
2: 70.4 percent / DNO3, D2SO4 / D2O / 6 h / -10 - 5 °C
View Scheme
参考文献
Spencer, Alwyn
Journal of Organometallic Chemistry, 1985 , vol. 295, p. 199 - 210
反应条件
1.1: hydrogenchloride / water / 20 °C
1.2: 1.17 h / 0 - 5 °C
1.3: 0 - 5 °C
2.1: sodium hydroxide / water / 3 h / 20 °C / pH 8 - 9
View Scheme
参考文献
Zhang, Ping; Zhang, Ying; Xue, Xiangdong; Wang, Chenjian; Wang, Zhongfu; Huang, Linjuan
Analytical Biochemistry, 2011 , vol. 418, # 1 p. 1 - 9
反应条件
1: With 4,4-dibromo-5-methyl-2,4-dihydro-3H-pyrazol-3-one in acetic acid
T=20°C; 15.5 h;
2: With potassium carbonate in water; acetic acid
pH=> 7;
参考文献
CONCERT PHARMACEUTICALS INC.; TUNG, Roger; MASSE, Craig, E.
Patent: WO2011/103457 A1, 2011 ;
Location in patent: Page/Page column 31; 32 ;
反应条件
hydrogenchloride; sodium nitrite
参考文献
Kirste, Burkhard; Kurrek, Harry; Sordo, Magdalena
Chemische Berichte, 1985 , vol. 118, # 5 p. 1782 - 1797
反应条件
1: 94.1 percent / benzene / Heating
2: 70.4 percent / DNO3, D2SO4 / D2O / 6 h / -10 - 5 °C
3: 71.7 percent / NaOH / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Spencer, Alwyn
Journal of Organometallic Chemistry, 1985 , vol. 295, p. 199 - 210
反应条件
1: 85 percent / 0.5 h / Heating
2: 70 percent / SOCl2; AlCl3 / CS2 / 6 h / Heating
View Scheme
参考文献
Gannett, Peter M.; Johnson II, Edward M.; Grimes, Michael A.; Myers, Alan L.; Deavers III, Robert E.; Tracy, Timothy S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 2 p. 107 - 114
