2-氨基-6-氯苯甲酸甲酯合成路线 （共 21 条）
反应条件
1: N-methyl-N-nitrosourea With sodium hydroxide in diethyl ether; water T=0°C; 0.5 h; 2: 2-amino-6-chloro-benzoic acid in diethyl ether T=20°C; 1 h;
参考文献
ASKA Pharmaceutical Co., Ltd.
Patent: EP1724267 A1, 2006 ;
Location in patent: Page/Page column 81 ;
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/14357 A2, 2004 ;
Location in patent: Page/Page column 34-35 ;
反应条件
in methanol; hexane; benzene T=20°C; 1 h;
参考文献
LIGAND PHARMACEUTICALS, INC.
Patent: WO2006/10142 A2, 2006 ;
Location in patent: Page/Page column 65 ;
WO 2006/010142 A2
反应条件
sodium hydroxide in methanol
参考文献
Imperial Chemical Industries, PLC
Patent: US5599814 A1, 1997 ;
反应条件
triethylamine in methanol
参考文献
BASF Aktiengesellschaft
Patent: US4306074 A1, 1981 ;
参考文献
Dr. Karl Thomae GmbH
Patent: US4404230 A1, 1983 ;
反应条件
hydrogenchloride in methanol 1 h; Heating;
参考文献
Schneller; Ibay; Martinson; Wells
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 972 - 978
Title/Abstract Full Text View citing articles Show Details
Schneller, Stewart W.; Ibay, Augusto C.; Christ, William J.; Bruns, Robert F.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2247 - 2254
反应条件
1: 1) galacial AcOH, 2) aq. MgSO4, KMnO4 / 1) reflux, 30 min, 2) 85-90 deg C, 1.5 h 2: 74 percent / diethyl ether / 0.5 h 3: HCl / methanol / 1 h / Heating View Scheme
参考文献
Schneller, Stewart W.; Ibay, Augusto C.; Christ, William J.; Bruns, Robert F.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2247 - 2254
反应条件
1: 74 percent / diethyl ether / 0.5 h 2: HCl / methanol / 1 h / Heating View Scheme
参考文献
Schneller, Stewart W.; Ibay, Augusto C.; Christ, William J.; Bruns, Robert F.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2247 - 2254
参考文献
BASF Aktiengesellschaft
Patent: US4306074 A1, 1981 ;
