甲基8-氯-8-氧代辛酸合成路线 （共 12 条）
反应条件
2: KOH / ethanol; H2O / 5 h / Heating
3: 74 percent / N2H4*H2O, KOH / bis-(2-hydroxy-ethyl) ether; methanol / 125 deg C, 6 h; 195 deg C, 3 h
View Scheme
参考文献
Dobner; Elsner; Nuhn
Pharmazie, 1989 , vol. 44, # 11 p. 758 - 760
反应条件
lithium aluminium tetrahydride; tert-butyl alcohol in diethylene glycol dimethyl ether
T=-60°C; 1 h;
参考文献
Iizuka; Akahane; Momose; Nakazawa; Tanouchi; Kawamura; Ohyama; Kajiwara; Iguchi; Okada; Taniguchi; Miyamoto; Hayashi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1139 - 1148
