甲基8-氯-8-氧代辛酸合成路线 （共 12 条）
反应条件
thionyl chloride 6 h; Heating;
参考文献
Iizuka; Akahane; Momose; Nakazawa; Tanouchi; Kawamura; Ohyama; Kajiwara; Iguchi; Okada; Taniguchi; Miyamoto; Hayashi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1139 - 1148
反应条件
N,N-dimethyl-formamide in benzene 1.) 5 deg C, 15 min; 2.) 23 deg C, 2 h; 3.) 60 deg C, 1 h;
参考文献
Tueting, David R.; Echavarren, Antonio M.; Stille, J. K.
Tetrahedron, 1989 , vol. 45, # 4 p. 979 - 992
反应条件
1: 34 percent / KOH / methanol / 4 h / 20 °C 2: SOCl2 / 3 h / 55 °C View Scheme
参考文献
Dobner; Elsner; Nuhn
Pharmazie, 1989 , vol. 44, # 11 p. 758 - 760
反应条件
1: 90 percent / H2SO4 / Heating 2: 34 percent / KOH / methanol / 4 h / 20 °C 3: SOCl2 / 3 h / 55 °C View Scheme
参考文献
Kern, Werner; Spiteller, Gerhard
Liebigs Annalen der Chemie, 1985 , # 5 p. 1168 - 1174
反应条件
T=-78°C; 0.0833333 h; Inert atmosphere;
参考文献
Ebert, Cynthia; Felluga, Fulvia; Forzato, Cristina; Foscato, Marco; Gardossi, Lucia; Nitti, Patrizia; Pitacco, Giuliana; Boga, Carla; Caruana, Paolo; Micheletti, Gabriele; Calonghi, Natalia; Masotti, Lanfranco
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 38 - 45
反应条件
(i) NaBH4, dioxane, (ii) (hydrolysis); Multistep reaction;
参考文献
Inanaga,J. et al.
Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 1989 - 1993
反应条件
1: pyridine / CH2Cl2 / 1) 1 h, 0 deg C, 2) 1 h, 20 deg C 2: aq. AcOH / 0.83 h / 80 - 90 °C View Scheme
参考文献
Zav'yalov, S. I.; Kravchenko, N. E.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 5.2 p. 1087 - 1090
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 5 p. 1195 - 1198
反应条件
triethylamine in dichloromethane 12 h; Heating;
参考文献
Mahboobi, Siavosh; Eichhorn, Emerich; Winkler, Matthias; Sellmer, Andreas; Moellmann, Ute
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 633 - 656
反应条件
1: DIEA / CH2Cl2 / 0.67 h / 0 - 20 °C 2: aq. LiOH / ethanol / 3 h / 20 °C View Scheme
参考文献
Anandan, Sampath-Kumar; Ward, John S.; Brokx, Richard D.; Bray, Mark R.; Patel, Dinesh V.; Xiao, Xiao-Xi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 8 p. 1969 - 1972
反应条件
ammonia in dichloromethane T=-78°C;
参考文献
Bertolini, Thomas M.; Giorgione, Jennifer; Harvey, Daniel F.; Newton, Alexandra C.
Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5028 - 5036
