2,2-二(2-甲基烯丙基)丙二酸二乙酯合成路线 （共 13 条）
反应条件
1: 88 percent / H2 / 10percent Pd/C / ethanol / 16 h / 760 Torr / Ambient temperature 2: 67 percent / 25percent KOH / ethanol / 20 h / Heating 3: 81 percent / SOCl2 / 6 h / Heating View Scheme
参考文献
Denmark, Scott E.; Nakajima, Norijuki; Nicaise, Olivier J.-C.; Faucher, Anne-Marie; Edwards, James P.
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4884 - 4892
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: 3-chloro-2-methyl-propene in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Li, Hua; Hong, Joon Hee
Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 8 p. 581 - 590
参考文献
Wasson,B.K. et al.
Canadian Journal of Chemistry, 1963 , vol. 41, p. 3070 - 3073
反应条件
sodium ethanolate in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Kirkland, Thomas A.; Grubbs, Robert H.
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7310 - 7318
反应条件
[VO(OEt)Cl2] in dichloromethane
16 h; Ambient temperature;
参考文献
Hirao; Sakaguchi; Ishikawa; Ikeda
Synthetic Communications, 1995 , vol. 25, # 17 p. 2579 - 2585
参考文献
Doran; Shonle
Journal of the American Chemical Society, 1937 , vol. 59, p. 1625
Full Text View citing articles Show Details
E.Lilly and Co.
Patent: US2106138 , 1937 ;
反应条件
1: 70 percent / NaH / tetrahydrofuran / 24 h / 60 °C
2: NaOEt / dimethylformamide / 20 °C
View Scheme
参考文献
Berlin, Jacob M.; Campbell, Katie; Ritter, Tobias; Funk, Timothy W.; Chlenov, Anatoly; Grubbs, Robert H.
Organic Letters, 2007 , vol. 9, # 7 p. 1339 - 1342
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 20°C; 0.25 h; Inert atmosphere;
2: 3-bromo-2-methylprop-1-ene in tetrahydrofuran; mineral oil
24 h; Inert atmosphereReflux;
参考文献
Iwasaki, Kotaro; Wan, Kanny K.; Oppedisano, Alberto; Crossley, Steven W. M.; Shenvi, Ryan A.
Journal of the American Chemical Society, 2014 , vol. 136, # 4 p. 1300 - 1303
反应条件
sodium hydride
1.) THF, room temperature, 30 min, 2.) THF, 24 h.; Yield given. Multistep reaction;
参考文献
Doyle, Michael P.; Peterson, Chad S.; Protopopova, Marina N.; Marnett, Alan B.; Parker Jr., Dann L.; Ene, Doina G.; Lynch, Vincent
Journal of the American Chemical Society, 1997 , vol. 119, # 38 p. 8826 - 8837
反应条件
[VO(OEt)Cl2] in dichloromethane
16 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Hirao; Sakaguchi; Ishikawa; Ikeda
Synthetic Communications, 1995 , vol. 25, # 17 p. 2579 - 2585
