3-甲氧基-4-氨基苯甲酸甲酯合成路线 （共 25 条）
反应条件
hydrogen; Raney nickel in methanol P=2327.23 Torr;
参考文献
Mok, N. Yi; Chadwick, James; Kellett, Katherine A. B.; Casas-Arce, Eva; Hooper, Nigel M.; Johnson, A. Peter; Fishwick, Colin W. G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1843 - 1852
反应条件
1: With sulfuric acid T=70°C; 24 h; 2: With sodium hydroxide in water pH=8;
参考文献
DECODE GENETICS EHF
Patent: US2009/130076 A1, 2009 ;
Location in patent: Page/Page column 31; 32 ;
US 20090130076 A1
反应条件
hydrogenchloride in methanol; ethyl acetate
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: EP1109560 B1, 2003 ;
反应条件
1: 91 percent / BF3 / 12 h 2: 91 percent / hydrogen / 10percent Pd/C / CH2Cl2; ethanol / 12 h View Scheme
参考文献
Mok, N. Yi; Chadwick, James; Kellett, Katherine A. B.; Casas-Arce, Eva; Hooper, Nigel M.; Johnson, A. Peter; Fishwick, Colin W. G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1843 - 1852
反应条件
1: 73 percent / potassium permanganate, sodium hydrogen carbonate / H2O / 4 h / Heating 2: 91 percent / BF3 / 12 h 3: 91 percent / hydrogen / 10percent Pd/C / CH2Cl2; ethanol / 12 h View Scheme
参考文献
Baret, Paul; Beaujolais, Virginie; Beguin, Claude; Gaude, Didier; Pierre, Jean-Louis; Serratrice, Guy
European Journal of Inorganic Chemistry, 1998 , # 5 p. 613 - 619
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 22 h / 25 - 30 °C / |Large scale 2: palladium 10 on activated carbon; hydrogen / 1,4-dioxane; methanol; water / 12 h / 35 - 40 °C View Scheme
参考文献
Ishikawa, Minoru; Tsushima, Masaki; Kubota, Dai; Yanagisawa, Yumiko; Hiraiwa, Yukiko; Kojima, Yasuo; Ajito, Keiichi; Anzai, Naomichi
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 596 - 602
反应条件
1: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 2: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 3: 69 percent / CuI / dimethylformamide / 2.5 h / 100 °C 4: 95 percent / KOH; H2O / ethanol / 24 h / Heating 5: 65 percent / Cu2O / quinoline / 4 h / 230 °C View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C;
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
反应条件
trifluorormethanesulfonic acid; IPy2BF4 in dichloromethane T=20°C; Iodination; 16 h;
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
1: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 2: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 3: 69 percent / CuI / dimethylformamide / 2.5 h / 100 °C 4: 95 percent / KOH; H2O / ethanol / 24 h / Heating View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
