3-氨基-1-苯基-2-吡唑啉-5-酮合成路线 （共 12 条）
反应条件
hydrogen; nickel in methanol T=40°C; P=2068.6 Torr; 6 h;
参考文献
Hyatt, John A.; Maggiulli, Cataldo A.; French, Stephen E.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 773 - 774
反应条件
hydrogenchloride in ethanol 1.5 h; Heating;
参考文献
Kim, Chang-Kyu; Zielinski, Paul A.; Maggiulli, Cataldo A.
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5247 - 5250
反应条件
1: 1.) conc. HCl, sodium nitrite; 2.) sodium ethoxide / 1.) water, 0-5 deg C; 2.) ethanol, 5-10 deg C 2: 75 percent / hydrogen / Raney nickel / methanol / 6 h / 40 °C / 2068.6 Torr View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 773 - 774
反应条件
1: 67 percent / hydroxylamine 2: 1. glacial acetic acid/RT/2 h 2. reflux/1.5 h 3: 42 percent / KOH / ethanol / 10 h / Heating 4: 71 percent / anhydrous hydrogen chloride / ethanol / 1.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, # 26 p. 5247 - 5250
反应条件
1: 1. glacial acetic acid/RT/2 h 2. reflux/1.5 h 2: 42 percent / KOH / ethanol / 10 h / Heating 3: 71 percent / anhydrous hydrogen chloride / ethanol / 1.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, # 26 p. 5247 - 5250
反应条件
1: 42 percent / KOH / ethanol / 10 h / Heating 2: 71 percent / anhydrous hydrogen chloride / ethanol / 1.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, # 26 p. 5247 - 5250
反应条件
phosphate buffer; water in propan-1-ol T=33°C; Rate constantMechanism;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 327, # 2 p. 209 - 219
反应条件
in 1,4-dioxane Heating;
参考文献
Cusan, Claudia; Spalluto, Giampiero; Prato, Maurizio; Adams, Michael; Bodensieck, Antje; Bauer, Rudolf; Tubaro, Aurelia; Bernardi, Paolo; Da Ros, Tatiana
Farmaco, 2005 , vol. 60, # 4 p. 327 - 332
反应条件
1: With PS-DIEA in tetrahydrofuran T=20°C; 12 h; 2: With N-(1-aminoethyl)aminomethylpolystyrene in tetrahydrofuran T=20°C;
参考文献
Fu, Jiasheng; Shuttleworth, Stephen J.
Tetrahedron Letters, 2003 , vol. 44, # 19 p. 3843 - 3845
反应条件
in 1,4-dioxane
Heating;
参考文献
Cusan, Claudia; Spalluto, Giampiero; Prato, Maurizio; Adams, Michael; Bodensieck, Antje; Bauer, Rudolf; Tubaro, Aurelia; Bernardi, Paolo; Da Ros, Tatiana
Farmaco, 2005 , vol. 60, # 4 p. 327 - 332
