3-氯-2,2-二甲基丙酰胺合成路线 （共 3 条）
反应条件
ammonia; sodium methylate in methanol T=60°C; 50 h; Autoclave;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
1.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube 1.2: 0.17 h / 0 - 20 °C 2.1: hydrogenchloride / 20 h / 20 °C View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
反应条件
1: With sodium hydroxide in methanol T=50 - 53°C; 70 h; Sealed tube; 2: With hydrogenchloride in methanol; water T=0 - 20°C; 0.166667 h;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 19 ;
