2-氨基-N-甲基苯甲酰胺合成路线 （共 35 条）
反应条件
1: N-methylamine hydrochloride With triethylamine in ethanol T=20°C; 0.0833333 h; 2: 2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine in ethanol 2 h; Inert atmosphereReflux;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; GARVAN INSTITUTE OF MEDICAL RESEARCH; DALY, Roger, John; HOLMES, Ian, Peter; STREET, Ian; WALKER, Scott, Raymond
Patent: WO2013/75167 A1, 2013 ;
Location in patent: Page/Page column 29 ;
反应条件
methylamine in tetrahydrofuran; methanol
参考文献
Takeda Chemical Industries, Inc.
Patent: US6407116 B1, 2002 ;
反应条件
in tetrahydrofuran; water 2.5 h;
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Husten, Jean; Lisko, Joseph G.; McHugh, Robert J.; Milkiewicz, Karen L.; Murthy, Seetha; Ott, Gregory R.; Theroff, Jay P.; Tripathy, Rabindranath; Underiner, Ted L.; Zificsak, Craig A.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 164 - 167
反应条件
1: anthranilic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=40°C; 2: methylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 23 p. 6041 - 6045
反应条件
1: 88 percent / sodium hydride / toluene / 0.25 h / 80 °C 2: acid / hydrolysis View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 43 p. 5255 - 5256
反应条件
1: phosgene / tetrahydrofuran / 20 °C 2: acetonitrile; water / 20 °C View Scheme
反应条件
hydrogenchloride; tin(ll) chloride T=100°C; 0.25 h;
参考文献
Li, Yanqiu; Zhan, Chunjing; Yang, Bingchuan; Cao, Xiaoqun; Ma, Chen
Synthesis (Germany), 2013 , vol. 45, # 1 art. no. SS-2012-H0697-OP, p. 111 - 117
参考文献
Tetrahedron Letters, , vol. 27, # 43 p. 5255 - 5256
反应条件
1: sulfuric acid / 0.25 h / 20 °C / |Reflux 2: 2 h / |Reflux 3: hydrogenchloride; tin(ll) chloride / 0.25 h / 100 °C View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 1 art. no. SS-2012-H0697-OP, p. 111 - 117
反应条件
1: 2 h / |Reflux 2: hydrogenchloride; tin(ll) chloride / 0.25 h / 100 °C View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 1 art. no. SS-2012-H0697-OP, p. 111 - 117
