4-(2-溴-乙氧基)-苯甲酸乙酯合成路线 （共 10 条）
参考文献
Abbott Laboratories
Patent: US4081447 A1, 1978 ;
反应条件
1: 1.) NaH / 1.) DMF, 90 deg C, 1 h, 2.) DMF, 90 deg C, 1 h 2: aq. NaOH / 1 h / Ambient temperature View Scheme
参考文献
Iizuka; Akahane; Momose; Nakazawa; Tanouchi; Kawamura; Ohyama; Kajiwara; Iguchi; Okada; Taniguchi; Miyamoto; Hayashi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1139 - 1148
反应条件
1: ethyl 4-hydroxy-benzoate With potassium carbonate in acetone
T=50°C; 0.5 h;
2: ethylene dibromide in acetone
T=50°C; 6 h;
参考文献
DR. REDDY'S LABORATORIES LTD
Patent: WO2005/40163 A1, 2005 ;
Location in patent: Page/Page column 64-65 ;
反应条件
sulfuric acid; sodium hydrogencarbonate in ethanol; water
参考文献
Hoechst Aktiengesellschaft
Patent: US3984459 A1, 1976 ;
反应条件
sodium bromide in acetone
12 h; Heating;
参考文献
Kotake; Okauchi; Iijima; Yoshimatsu; Nomura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 829 - 841
反应条件
1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h
2: 93 percent / 1N NaOH / ethanol / 3 h / Ambient temperature
3: 100 percent / NaBH4*Et2O / tetrahydrofuran / -78 - 20 °C
4: NaBr / acetone / 12 h / Heating
View Scheme
参考文献
Kotake; Okauchi; Iijima; Yoshimatsu; Nomura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 829 - 841
反应条件
1: 100 percent / NaBH4*Et2O / tetrahydrofuran / -78 - 20 °C
2: NaBr / acetone / 12 h / Heating
View Scheme
参考文献
Kotake; Okauchi; Iijima; Yoshimatsu; Nomura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 829 - 841
反应条件
1: 93 percent / 1N NaOH / ethanol / 3 h / Ambient temperature
2: 100 percent / NaBH4*Et2O / tetrahydrofuran / -78 - 20 °C
3: NaBr / acetone / 12 h / Heating
View Scheme
参考文献
Kotake; Okauchi; Iijima; Yoshimatsu; Nomura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 829 - 841
反应条件
potassium hydroxide in ethanol
参考文献
Leroux; Fritz; Doane; Chien
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 1995 , vol. 261, # pt 2 p. 465 - 480
反应条件
1: acetic acid; aqueous H2SO4
2: aqueous NH3
View Scheme
参考文献
Eastman Kodak Co.
Patent: US2790825 , 1956 ;
