2-(4-苯基-1,3-噻唑-2-基)乙腈合成路线 （共 7 条）
反应条件
in DMF (N,N-dimethyl-formamide) T=70°C; 1 h;
参考文献
NOVUSPHARMA S.P.A.
Patent: WO2003/105842 A1, 2003 ;
Location in patent: Page 65 - 66 ;
反应条件
1: acetonitrile With sodium hexamethyldisilazane in tetrahydrofuran T=-60°C; 0.5 h; 2: 4-phenyl-2-chlorothiazole in tetrahydrofuran T=0°C; 1 h;
参考文献
Shionogi and Co., Ltd.
Patent: EP2351744 A1, 2011 ;
Location in patent: Page/Page column 59-60 ;
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Hussain, Sohair Mohamed; El-Reedy, Ahmed Mohamed; El-Sharabasy, Salwa Ahmed
Tetrahedron, 1988 , vol. 44, # 1 p. 241 - 246
反应条件
1: 95 percent / piperidine / ethanol / 2 h / Heating 2: hydrazine hydrate / ethanol / 5 h / Heating View Scheme
参考文献
Hussain, Sohair Mohamed; El-Reedy, Ahmed Mohamed; El-Sharabasy, Salwa Ahmed
Tetrahedron, 1988 , vol. 44, # 1 p. 241 - 246
反应条件
1.1: copper dichloride; isopentyl nitrite / acetonitrile / 3 h / 50 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C 2.2: 1 h / 0 °C View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2351744 A1, 2011 ;
反应条件
1: With water; sodium hydroxide in ethanol 1 h; Reflux; 2: With hydrogenchloride in ethanol; water
参考文献
Shionogi and Co., Ltd.
Patent: EP2351744 A1, 2011 ;
Location in patent: Page/Page column 60 ;
反应条件
2: KOH / ethane-1,2-diol View Scheme
参考文献
Schaefer,H.; Gewald,K.
Journal fuer Praktische Chemie (Leipzig), 1974 , vol. 316, p. 684 - 692
