2,4,6-三氯苯甲酰氯合成路线 （共 16 条）
反应条件
phosphorus pentachloride
参考文献
Inanaga,J. et al.
Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 1989 - 1993
反应条件
1: 1.) concd. H2SO4, NaNO2 / 1.) HOAc, 15 deg C, 3 h, 2.) H2O, 35-40 deg C, 1 h 2: 40.8 percent / concd. H2SO4 / 3 h / Heating 3: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 4: SOCl2, DMF / 3 h / Heating 5: SOCl2, DMF / 3 h / Heating View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
反应条件
1: 40.8 percent / concd. H2SO4 / 3 h / Heating 2: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 3: SOCl2, DMF / 3 h / Heating 4: SOCl2, DMF / 3 h / Heating View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
反应条件
1: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 2: SOCl2, DMF / 3 h / Heating 3: SOCl2, DMF / 3 h / Heating View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
反应条件
1: 1.) Br2, HOAc, 2.) 50percent aq. NaOH / 0.5 h / Ambient temperature 2: 1.) concd. H2SO4, NaNO2 / 1.) HOAc, 15 deg C, 3 h, 2.) H2O, 35-40 deg C, 1 h 3: 40.8 percent / concd. H2SO4 / 3 h / Heating 4: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 5: SOCl2, DMF / 3 h / Heating 6: SOCl2, DMF / 3 h / Heating View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
反应条件
1: acetic acid; sulfuric acid; water 2: phosphorus (V)-chloride View Scheme
参考文献
Fuson; Bertetti; Ross
Journal of the American Chemical Society, 1932 , vol. 54, p. 4380,4382
反应条件
thionyl chloride; N,N-dimethyl-formamide 3 h; Heating;
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
反应条件
1: SOCl2, DMF / 3 h / Heating 2: SOCl2, DMF / 3 h / Heating View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
反应条件
water; triethylamine in acetone T=20°C; 18 h;
参考文献
Dhimitruka, Ilirian; SantaLucia Jr., John
Organic Letters, 2006 , vol. 8, # 1 p. 47 - 50
反应条件
1: 3-phenyl-2E-propenoic acid; 2,4,6-trichlorobenzoyl chloride With triethylamine in tetrahydrofuran T=20°C; Yamaguchi reaction; Inert atmosphere; 2: Hydrocinnamic alcohol With 4-(N,N-dimethlyamino)pyridine in benzene T=20°C; Yamaguchi reaction; Inert atmosphere; chemoselective reaction;
参考文献
Heterocycles, , vol. 76, # 2 p. 1313 - 1328
