螺[1-氮杂双环[2.2.2]辛烷-3,2'-环氧乙烷]合成路线 （共 7 条）
反应条件
hydrogen sulfide in methanol; dichloromethane T=0 - 5°C;
参考文献
Pramanik, Chinmoy; Patil, Pradip; Kotharkar, Sandeep; Tripathy, Narendra K.; Gurjar, Mukund K.
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3043 - 3045
反应条件
1: hydrogen bromide / acetone; water / 2 h / 0 - 20 °C 2: water / 2 h / 100 - 110 °C / |Green chemistry 3: sodium hydroxide / water / 2 h / 100 °C / |Green chemistry 4: boron trifluoride diethyl etherate / dichloromethane View Scheme
参考文献
Pramanik, Chinmoy; Patil, Pradip; Kotharkar, Sandeep; Tripathy, Narendra K.; Gurjar, Mukund K.
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3043 - 3045
反应条件
1.1: isopropyl alcohol / 2 h / 0 - 20 °C 2.1: toluene-4-sulfonic acid / isopropyl alcohol / 3.5 h / |Reflux 2.2: 3 h / |Reflux View Scheme
参考文献
Pramanik, Chinmoy; Patil, Pradip; Kotharkar, Sandeep; Tripathy, Narendra K.; Gurjar, Mukund K.
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3043 - 3045
反应条件
sodium hydride in tetrahydrofuran; dimethyl sulfoxide; mineral oil
T=15°C; Reflux;
参考文献
Pierre Fabre Medicament
Patent: US2010/105897 A1, 2010 ;
Location in patent: Page/Page column 1-2 ;
反应条件
potassium tert-butylate; trimethyl-oxo-sulfonium iodide in dimethyl sulfoxide
T=0 - 20°C; 16.75 h;
参考文献
Apotex Pharmachem Inc.
Patent: US2008/249312 A1, 2008 ;
Location in patent: Page/Page column 2-3 ;
反应条件
potassium tert-butylate in dimethyl sulfoxide
T=0 - 20°C; 16.75 h; Inert atmosphere;
参考文献
APOTEX PHARMACHEM INC.; Stewart, Craig; Johansen, Michael B.; Datta, Probal Kanti; Zhao, Yajun
Patent: US2013/274474 A1, 2013 ;
Location in patent: Paragraph 0076-0078 ;
反应条件
perchloric acid
T=20°C; Ring cleavage; 18 h;
参考文献
Mullen; Napier; Balestra; Decory; Hale; Macor; Mack; Loch III; Wu; Kover; Verhoest; Sampognaro; Phillips; Zhu; Murray; Griffith; Blosser; Gurley; Machulskis; Zongrone; Rosen; Gordon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4045 - 4050
