6-羟基甲基-吡啶-2-羧酸乙酯合成路线 （共 12 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran 2 h; Reflux;
参考文献
Spaeth, Andreas; Gonschor, Janina; Koenig, Burkhard
Monatshefte fur Chemie, 2011 , vol. 142, # 12 p. 1289 - 1308
反应条件
1: toluene / 24 h 2: 69 percent / NaBH4 / ethanol / 48 h / -20 °C View Scheme
参考文献
Fife, Thomas H.; Przystas, Theodore J.
Journal of the American Chemical Society, 1982 , vol. 104, # 8 p. 2251 - 2257
反应条件
1: SOCl2 / 12 h / Heating 2: toluene / 24 h 3: 69 percent / NaBH4 / ethanol / 48 h / -20 °C View Scheme
参考文献
Fife, Thomas H.; Przystas, Theodore J.
Journal of the American Chemical Society, 1982 , vol. 104, # 8 p. 2251 - 2257
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in water P=760 Torr; 16 h; also other pyridine esters; var. catalysts and conditions; Product distribution;
参考文献
Bolos; Gubert; Anglada; Perez; Sacristan; Ortiz
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1493 - 1496
参考文献
Chatterton, Nicholas; Gateau, Christelle; Mazzanti, Marinella; Pecaut, Jacques; Borel, Alain; Helm, Lothar; Merbach, Andre
Dalton Transactions, 2005 , # 6 p. 1129 - 1135
反应条件
sodium hydroxide 12 h; Ambient temperature;
参考文献
Vergopoulos, Vassilios; Jantzen, Sven; Julien, Nathalie; Rose, Eric; Rehder, Diether
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1994 , vol. 49, # 8 p. 1127 - 1136
反应条件
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine in dichloromethane T=4 - 20°C; Parikh-Doering oxidation;
参考文献
Downey, Jason D.; Saleh, Sam A.; Bridges, Thomas M.; Morrison, Ryan D.; Scott Daniels; Lindsley, Craig W.; Breyer, Richard M.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 37 - 41
反应条件
1: 1.) selenium dioxide; 2.) hydroxylamine hydrochloride / 1.) dioxane, reflux, 3 h; 2.) H2O-dioxane, RT, 30 min 2: Et3N / acetonitrile / 2 h / Ambient temperature View Scheme
参考文献
Suh, Junghun; Han, Oksoo; Chang, Bomee
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 1839 - 1842
反应条件
1: 96 percent / SOCl2 / 0 °C 2: 92 percent / dimethylformamide / 20 °C 3: 100 percent / H2NNH2*H2O / ethanol / Heating View Scheme
参考文献
Fornasier, Roberto; Milani, Daria; Scrimin, Paolo; Tonellato, Umberto
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 233 - 238
反应条件
1: 91 percent / SOCl2, Na2CO3 / H2O 2: 72 percent / acetonitrile View Scheme
参考文献
Julien-Cailhol, Nathalie; Rose, Eric; Vaisserman, Jaqueline; Rehder, Dieter
Journal of the Chemical Society - Dalton Transactions, 1996 , # 10 p. 2111 - 2115
