N-Cbz-DL-丙氨酸合成路线 （共 26 条）
反应条件
1: 6.23 g / industrial papain / 6 h / 50 °C / pH 4,5 (1 N Na2CO3, cysteamine*HCl, buffer citrate)
2: 5.4 g / 2 N NaOH / methanol
View Scheme
参考文献
Moriniere, Jean-Luc; Danree, Bernard; Guy, Alain
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 347 - 358
反应条件
dicyclohexyl-carbodiimide in ethylene glycol dimethyl ether
T=0°C;
参考文献
Detsi, Anastasia; Micha-Screttas, Maria; Igglessi-Markopoulou, Olga
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2443 - 2449
反应条件
trichlorophosphate in tetrahydrofuran
参考文献
Thorberg; Berg; Lundstrom; Pettersson; Wijkstrom; Sanchez; Lindberg; Nilsson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2008 - 2012
反应条件
industrial papain
T=50°C; 6 h; pH 4,5 (1 N Na2CO3, cysteamine*HCl, buffer citrate);
参考文献
Moriniere, Jean-Luc; Danree, Bernard; Guy, Alain
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 347 - 358
反应条件
sulfuryl dichloride in 1,1,2,2-tetrachloroethylene
参考文献
Taschner,E.; Wasielewski,C.
Justus Liebigs Annalen der Chemie, 1961 , vol. 640, p. 139 - 141
参考文献
Ben-Ishai; Berger
Journal of Organic Chemistry, 1952 , vol. 17, p. 1564,1565
