5-甲氧基-1H-吡唑-3-胺合成路线 （共 6 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 4 p. 1017 - 1021
反应条件
hydrazine T=120°C; 1 h;
参考文献
WO2005/49033 A1, ;
Page/Page column 115-116 ;
WO 2005/049033 A1
反应条件
1: With azodicarboxylate; triphenylphosphine in tetrahydrofuran T=10 - 20°C; 16 h; 2: With hydrazine in tetrahydrofuran T=20°C; 1 h; Product distribution / selectivity;
参考文献
EP2070932 A1, ;
Page/Page column 45 ;
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=18 - 25°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 1 p. 262 - 276
反应条件
in water T=90°C; 16 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; LAIRD, Ellen; MORENO, David; REN, Li; WENGLOWSKY, Steven Mark
Patent: WO2011/25968 A1, 2011 ;
Location in patent: Page/Page column 42 ;
WO 2011/025968 A1
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 1017 - 1021
