2-(5-溴-4-氧代戊基)-1H-异吲哚-1,3(2H)-二酮合成路线 （共 16 条）
反应条件
1: 88 percent 2: 92 percent / SOCl2 4: 48percent HBr/H2O / acetic acid View Scheme
参考文献
Tolstikov, G. A.; Galin, F. Z.; Lakeev, S. N.; Khalilov, L. M.; Sultanova, V. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 535 - 541
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 612 - 620
反应条件
1: 60 percent 2: 22 percent / Br2 / methanol; butan-1-ol; dioxane / 50 - 55 °C View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
1: hydrochloric acid; acetic acid; water 2: thionyl chloride / und Behandeln des Reaktionsprodukts in Benzol mit Diazomethan in Aether 3: acetic acid; water; hydrobromic acid View Scheme
参考文献
Michalsky et al.
Chemicke Listy, 1955 , vol. 49, p. 1379,1381
Chem.Abstr., 1956 , p. 5681
反应条件
1: silver oxide 2: hydrochloric acid; acetic acid; water 3: thionyl chloride / und Behandeln des Reaktionsprodukts in Benzol mit Diazomethan in Aether 4: acetic acid; water; hydrobromic acid View Scheme
参考文献
Michalsky et al.
Chemicke Listy, 1955 , vol. 49, p. 1379,1381
Chem.Abstr., 1956 , p. 5681
反应条件
hydrogen bromide Yield given. Multistep reaction;
参考文献
Tolstikov, G. A.; Galin, F. Z.; Lakeev, S. N.; Khalilov, L. M.; Sultanova, V. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 535 - 541
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 612 - 620
反应条件
in N,N-dimethyl-formamide
T=120°C; 3 h;
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
