2-(5-溴-4-氧代戊基)-1H-异吲哚-1,3(2H)-二酮合成路线 （共 16 条）
反应条件
1: 4(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyric acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 1 h; 2: diazomethane in diethyl ether; dichloromethane T=0°C; 1.5 h; 3: With hydrogen bromide in diethyl ether; dichloromethane; water
参考文献
North Carolina State University
Patent: US2008/181923 A1, 2008 ;
Location in patent: Page/Page column 44 ;
反应条件
2: 48percent HBr/H2O / acetic acid View Scheme
参考文献
North Carolina State University
Patent: US2009/143230 A1, 2009 ;
Location in patent: Page/Page column 51 ;
反应条件
bromine in methanol 24 h; Ambient temperature;
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
bromine; urea in methanol 24 h;
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
water; hydrogen bromide; acetic acid
参考文献
Yang, Ya-Jun; Zhao, Jing-Hua; Pan, Xian-Dao; Zhang, Pei-Cheng
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 2 p. 208 - 211
参考文献
Geyer, Roland; Kaske, Melanie; Baumeister, Paul; Buschauer, Armin
Archiv der Pharmazie, 2014 , vol. 347, # 2 p. 77 - 88
反应条件
1: 90 percent / NaOEt / ethyl acetate; ethanol / 1.) RT, 2 h, 2.) reflux, 2 h 2: 52 percent / Br2 / methanol / 24 h / Ambient temperature View Scheme
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
bromine; urea in methanol T=20°C; 24 h;
参考文献
Geyer, Roland; Kaske, Melanie; Baumeister, Paul; Buschauer, Armin
Archiv der Pharmazie, 2014 , vol. 347, # 2 p. 77 - 88
反应条件
1: 92 percent / SOCl2 3: 48percent HBr/H2O / acetic acid View Scheme
参考文献
Michalsky et al.
Chemicke Listy, 1955 , vol. 49, p. 1379,1381
Chem.Abstr., 1956 , p. 5681
反应条件
1: 60 percent 2: 22 percent / Br2 / methanol; butan-1-ol; dioxane / 50 - 55 °C View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
