2-(4-氯丁氧基)四氢吡喃合成路线 （共 19 条）
反应条件
pyridinium p-toluenesulfonate in dichloromethane T=20°C;
参考文献
Guan, Jian; Kyle, Dennis E.; Gerena, Lucia; Zhang, Quan; Milhous, Wilbur K.; Lin, Ai J.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2741 - 2748
反应条件
chlorodimethyl(phenylthio)chloride methanaminium; triethylamine in dichloromethane T=20°C; Chlorination; 3 h;
参考文献
Gomez; Gellibert; Wagner; Mioskowski
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6049 - 6052
反应条件
sodium hydrogencarbonate; magnesium bromide in tetrahydrofuran Ambient temperatureovernight (15-24 hrs);
参考文献
Brown, Dearg S.; Ley, Steven V.; Vile, Sadie; Thompson, Mervyn
Tetrahedron, 1991 , vol. 47, # 7 p. 1329 - 1342
反应条件
in dichloromethane T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
Ushakov, Dmitry B.; Maier, Martin E.
Synlett, 2013 , vol. 24, # 6 art. no. ST-2013-B0022-L, p. 705 - 708
反应条件
1: 1,3-Dithiane With n-butyllithium in tetrahydrofuran; hexane T=-78 - -28°C; 2.5 h; 2: 4-chloro-1-(tetrahydropyran-2-yl-oxy)-n-butane in tetrahydrofuran; hexane T=-78°C; 2 h; Further stages.;
参考文献
Lee, Sangku; Zhao, Zuchun
Organic Letters, 1999 , vol. 1, # 4 p. 681 - 683
反应条件
ammonium cerium(IV) nitrate in alkaline aq. solution; acetonitrile T=70°C; Decomposition; pH=8; 2 h;
参考文献
Marko, Istvan E.; Ates, Ali; Augustyns, Benoit; Gautier, Arnaud; Quesnel, Yannick; Turet, Laurent; Wiaux, Marianne
Tetrahedron Letters, 1999 , vol. 40, # 30 p. 5613 - 5616
反应条件
aluminum oxide; Oxonereg;; water in methanol T=50°C; Yield givenYields of byproduct given;
参考文献
Curini, Massimo; Epifano, Francesco; Marcotullio, Maria Carla; Rosati, Ornelio
Synlett, 1999 , # 6 p. 777 - 779
反应条件
Yield given. Multistep reaction;
参考文献
Rossi, Renzo; Carpita, Adriano
Tetrahedron, 1983 , vol. 39, # 2 p. 287 - 290
反应条件
(i) LiNEt2, HMPT, benzene, (ii) K, HMPT, tBuOH, (iii) TsOH; Multistep reaction;
参考文献
Debal,A. et al.
Synthesis, 1976 , p. 391 - 393
反应条件
in dimethyl sulfoxide T=25°C; 8 h;
参考文献
Nystroem, Jan-E.; McCanna, Terrence D.; Helquist, Paul; Iyer, Ramnath S.
Tetrahedron Letters, 1985 , vol. 26, # 44 p. 5393 - 5396
