4-甲氨基-3-硝基苯甲酸合成路线 （共 30 条）
反应条件
in methanol; ethanol T=20°C; 2 h;
参考文献
Kuzniewski, Christian N.; Gertsch, Jurg; Wartmann, Markus; Altmann, Karl-Heinz
Organic Letters, 2008 , vol. 10, # 6 p. 1183 - 1186
反应条件
1: in DMF (N,N-dimethyl-formamide); water T=20°C; 1 h; 2: With potassium hydrogensulfate in water pH=2;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 244 ;
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; water T=20°C; 16 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=Ca. 5;
参考文献
GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; DIALLO, Hawa; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; SHEPPARD, Robert John; WALKER, Ann, Louise; WELLAWAY, Christopher; WILSON, David Matthew
Patent: WO2014/15905 A1, 2014 ;
Location in patent: Page/Page column 50; 51 ;
反应条件
1: With triethylamine in methanol; ethanol T=20°C; 24 h; 2: With acetic acid in water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PFAU, Roland; ARNDT, Kirsten; DOODS, Henri; KLINDER, Klaus; KUELZER, Raimund; LUBRIKS, Dimitrijs; MACK, Juergen; PELCMAN, Benjamin; PRIEPKE, Henning; ROENN, Robert; STENKAMP, Dirk; SUNA, Edgars
Patent: WO2010/100249 A1, 2010 ;
Location in patent: Page/Page column 81-82 ;
WO 2010/100249 A1
反应条件
in water T=100°C; 14 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0291 ;
反应条件
methylamine in water
参考文献
Church, Timothy J.; Cutshall, Neil Scott; Gangloff, Anthony R.; Jenkins, Thomas E.; Linsell, Martin S.; Litvak, Joane; Rice, Kenneth D.; Spencer, Jeffrey R.; Wang, Vivian R.
Patent: US2001/53779 A1, 2001 ;
反应条件
1.1: N,N-dimethyl-formamide / 70 - 90 °C / |Inert atmosphere 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 16 h / 20 °C 2.2: pH Ca. 5 View Scheme
参考文献
GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; DIALLO, Hawa; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; SHEPPARD, Robert John; WALKER, Ann, Louise; WELLAWAY, Christopher; WILSON, David Matthew
Patent: WO2014/15905 A1, 2014 ;
反应条件
potassium permanganate; sodium carbonate
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
反应条件
potassium permanganate; sodium carbonate
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
参考文献
Thieme
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 464
