bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in 1,4-dioxane T=20 - 100°C; Suzuki Coupling; Inert atmosphere;

cesium fluoride in tetrahydrofuran T=85°C; Suzuki-Miyaura reaction; 0.5 h; microwave irradiation;

1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 - -20 °C 1.2: tetrahydrofuran / 3 h / -78 - 20 °C 1.3: 89 percent / AcOH; H2SO4 / tetrahydrofuran / 0.08 h / 120 °C 2.1: 98 percent / POPd; CsF / tetrahydrofuran / 0.5 h / 85 °C / microwave irradiation View Scheme

1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 - -20 °C 1.2: tetrahydrofuran / 3 h / -78 - 20 °C 1.3: 89 percent / AcOH; H2SO4 / tetrahydrofuran / 0.08 h / 120 °C 2.1: 98 percent / POPd; CsF / tetrahydrofuran / 0.5 h / 85 °C / microwave irradiation View Scheme

1: 4-bromo-2'-hydroxylchalcone With zinc(II) chloride in dichloromethane T=20°C; 12 h; 2: 3,4,5-trimethoxyphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether Suzuki coupling; Inert atmosphereReflux; 3: With dihydrogen peroxide in tetrahydrofuran; water T=0°C; 1 h; regioselective reaction;

diphenyldisulfane T=260 - 290°C; 2.5 h;

1: pyridine; potassium hydroxide / 2 h / 60 °C 2: sulfuric acid / methanol / 1 h / Reflux 3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; N,N-dimethyl-formamide / 0.03 h / Microwave irradiation View Scheme

1: sulfuric acid / methanol / 1 h / Reflux 2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; N,N-dimethyl-formamide / 0.03 h / Microwave irradiation View Scheme

1.1: AlCl3, aluminium chloride 2.1: montmorillonite-KSF catalyst / 1,2-dichloro-ethane / 0.25 h 2.2: 3 h / 75 - 81 °C 3.1: pyridine; potassium hydroxide / 2 h / 60 °C 4.1: sulfuric acid / methanol / 1 h / Reflux 5.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; N,N-dimethyl-formamide / 0.03 h / Microwave irradiation View Scheme

1.1: sodium hydroxide 2.1: AlCl3, aluminium chloride 3.1: montmorillonite-KSF catalyst / 1,2-dichloro-ethane / 0.25 h 3.2: 3 h / 75 - 81 °C 4.1: pyridine; potassium hydroxide / 2 h / 60 °C 5.1: sulfuric acid / methanol / 1 h / Reflux 6.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; N,N-dimethyl-formamide / 0.03 h / Microwave irradiation View Scheme