sodium ethanolate in N,N-dimethyl-formamide T=90 - 100°C; 8 h;
参考文献
Terpigorev, A. N.; Shcherbinin, M. B.; Bazanov, A. G.; Tselinskii, I. V.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, # 2 p. 407
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 2 p. 463
1: 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester With methanesulfonyl chloride 2: 1,2,4-Triazole sodium salt 3: With hydrogenchloride
参考文献
AMICUS THERAPEUTICS, INC.
Patent: WO2006/133098 A2, 2006 ;
Location in patent: Page/Page column 2/18 ;