2’-溴-3,4-二氯苯乙酸乙酯合成路线 (共 4 条)
反应条件
N-bromosuccinmide; hydrogen bromide in tetrachloromethane Heating;
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: H2SO4 / benzene 2: NBS / CCl4 / 5 h / Irradiation View Scheme
参考文献
EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter
Patent: WO2012/75473 A1, 2012 ;
反应条件
1: 29 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
2: 40 percent / KOH / ethanol; H2O / 6 h / Heating
3: 84 percent / urea / xylene / Heating
4: 65 percent / BH3 / tetrahydrofuran / 1 h / 100 °C
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 29 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
2: 40 percent / KOH / ethanol; H2O / 6 h / Heating
3: 84 percent / urea / xylene / Heating
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490