4-[(E)-2-(3,5-二羟基苯基)乙烯基]苯基乙酸酯合成路线 （共 18 条）
反应条件
sodium hydroxide in tetrahydrofuran 2 h; Heating;
参考文献
Moro, Angelica Venturini; Cardoso, Flavio Sega P.; Correia, Carlos Roque D.
Tetrahedron Letters, 2008 , vol. 49, # 39 p. 5668 - 5671
反应条件
chloro-trimethyl-silane; sodium iodide in dichloromethane; acetonitrile
0.25 h;
参考文献
Wong, Yong; Osmond, Gregory; Brewer, Kenneth I.; Tyler, Douglas S.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1198 - 1201
反应条件
dimethylsulfide; boron trifluoride diethyl etherate in dichloromethane
20 h; Inert atmosphere;
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
1: (E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)-ethene With triethylamine in dimethyl sulfoxide
T=65°C; 0.333333 h;
2: acetic anhydride in dimethyl sulfoxide
T=65°C; 1 h;
参考文献
Acerson, Mark J.; Andrus, Merritt B.
Tetrahedron Letters, 2014 , vol. 55, # 3 p. 757 - 760
反应条件
anhydrous iron chloride in tetrahydrofuran
T=20°C; 0.75 h; Reagent/catalystTemperatureSolvent;
参考文献
Acerson, Mark J.; Andrus, Merritt B.
Tetrahedron Letters, 2014 , vol. 55, # 3 p. 757 - 760
反应条件
boron trichloride; tetra-(n-butyl)ammonium iodide in dichloromethane
T=0 - 20°C; 2 h;
参考文献
Moro, Angelica Venturini; Cardoso, Flavio Sega P.; Correia, Carlos Roque D.
Tetrahedron Letters, 2008 , vol. 49, # 39 p. 5668 - 5671
反应条件
Candida antarctica lipase in 1,1-dimethylpropan-1-ol
T=40°C; 90 h;
参考文献
Cardile, Venera; Lombardo, Laura; Spatafora, Carmela; Tringali, Corrado
Bioorganic Chemistry, 2005 , vol. 33, # 1 p. 22 - 33
反应条件
1: 59 percent / 1,3-bis-(2,6-diisopropylphenyl)imidazolinium chloride; N-methylmorpholine / Pd(OAc)2 / xylene / 3.5 h / 120 °C
2: 72 percent / NaI; trimethylsilyl chloride / CH2Cl2; acetonitrile / 0.25 h
View Scheme
参考文献
Andrus, Merritt B.; Liu, Jing
Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5811 - 5814
反应条件
1: 59 percent / 1,3-bis-(2,6-diisopropylphenyl)imidazolinium chloride; N-methylmorpholine / Pd(OAc)2 / xylene / 3.5 h / 120 °C
2: 72 percent / NaI; trimethylsilyl chloride / CH2Cl2; acetonitrile / 0.25 h
View Scheme
参考文献
Andrus, Merritt B.; Liu, Jing
Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5811 - 5814
反应条件
1.1: NaH / dimethylformamide; various solvent(s) / 1.33 h
1.2: dimethylformamide; various solvent(s) / 30 h / 50 °C
1.3: 91 percent / NaOH / methanol; H2O / 3 h
2.1: 97 percent / SOCl2; benzotriazole / CH2Cl2 / 0.17 h
3.1: 59 percent / 1,3-bis-(2,6-diisopropylphenyl)imidazolinium chloride; N-methylmorpholine / Pd(OAc)2 / xylene / 3.5 h / 120 °C
4.1: 72 percent / NaI; trimethylsilyl chloride / CH2Cl2; acetonitrile / 0.25 h
View Scheme
参考文献
Andrus, Merritt B.; Liu, Jing
Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5811 - 5814
