4-(1H-苯并[d]咪唑-2-基)苯甲腈合成路线 （共 15 条）
反应条件
sodium hydroxide Heating;
参考文献
Zhang, Rui; Lei, Lin; Xu, Yun-Gen; Hua, Wei-Yi; Gong, Guo-Qing
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2430 - 2433
反应条件
ammonium acetate in ethanol
T=75°C; 5.5 h;
参考文献
Sharghi, Hashem; Asemani, Omid; Khalifeh, Reza
Synthetic Communications, 2008 , vol. 38, # 7 p. 1128 - 1136
反应条件
exo/endo-9-cyclohexyl-9-phospabicyclo[4.2.1]nonane; isobutyldiisopropylamine; [RhCl(cis-cyclooctene)2]2 in 1,2-dichloro-benzene
T=250°C; 0.666667 h; microwave irradiation;
参考文献
Lewis, Jared C.; Wu, Jessica Y.; Bergman, Robert G.; Ellman, Jonathan A.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 10 p. 1589 - 1591
反应条件
2,6-dimethylpyridine; bis(triphenylphosphine)palladium(II)-chloride in N,N-dimethyl acetamide
T=140°C; P=4912.9 Torr; 24 h;
参考文献
Perry; Wilson
Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 7016 - 7021
反应条件
potassium fluoride/aluminium oxide; magnesium sulfate in acetonitrile
T=20°C; 0.75 h;
参考文献
Khalili, Saeed Bahadori; Sardarian, Ali Reza
Monatshefte fur Chemie, 2012 , vol. 143, # 5 p. 841 - 846
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium carbonate in water; acetonitrile
T=150°C; Suzuki coupling; 0.5 h; Microwave irradiation;
参考文献
Savall, Brad M.; Fontimayor, Jill R.
Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6667 - 6669
反应条件
polyphosphoric acid
T=140°C; 4 h;
参考文献
Lim, Chae Jo; Kim, Nakjeong; Lee, Eun Kyoung; Lee, Byung Ho; Oh, Kwang-Seok; Yoo, Sung-Eun; Yi, Kyu Yang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2309 - 2312
反应条件
1: in acetonitrile
0.0833333 h;
2: With N-iodo-succinimide in acetonitrile
T=20°C; 0.7 h;
参考文献
Bhattacharyya, Bhaswati; Dhara, Kaliprasanna
Journal of the Indian Chemical Society, 2013 , vol. 90, # 10 p. 1749 - 1759
反应条件
copper(I) oxide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in water
T=100°C; 30 h; Sealed tube;
参考文献
Peng, Jinsong; Ye, Min; Zong, Cuijuan; Hu, Fangyun; Feng, Lingtong; Wang, Xiaoyan; Wang, Yufeng; Chen, Chunxia
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 716 - 719
反应条件
1: 99 percent Chromat. / 3 Angstroem molecular sieves; DBU; carbon monoxide / Se / dioxane / 3 h / 120 °C / 22800 Torr
View Scheme
参考文献
Nishiyama, Yutaka; Fujimoto, Mayu; Sonoda, Noboru
Synlett, 2006 , # 1 art. no. U26605ST, p. 109 - 111
