H-ALA-ALA-OME · HCL合成路线 （共 9 条）
反应条件
1: 85 percent / NEM, DCCI / CH2Cl2; dimethylformamide / 20 h / 0 °C 2: 85 percent / 1) 1 N NaOH / methanol / 2 h / Ambient temperature 3: H2 / 10percent Pd/C / methanol View Scheme
参考文献
Brueckner; Jung
1980 , vol. No. 1, p. 37 - 49
反应条件
chloroformic acid ethyl ester; triethylamine in tetrahydrofuran; N,N-dimethyl-formamide 1.) -10 deg C, pH 7.5, 1 h; 2.) 4 deg C, overnight;
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
反应条件
1: 84 percent / NEt3, ethyl chlorocarbonate / tetrahydrofuran; dimethylformamide / 1.) -10 deg C, pH 7.5, 1h; 2.) 4 deg C, overnight 2: 100 percent / 2 N HCl, H2 / Pd / methanol 3: pyridine / 3 h / Ambient temperature View Scheme
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
反应条件
in pyridine 3 h; Ambient temperature;
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
反应条件
1: 85 percent / NEM, DCCI / CH2Cl2; dimethylformamide / 20 h / 0 °C 2: 85 percent / 1) 1 N NaOH / methanol / 2 h / Ambient temperature View Scheme
参考文献
Brueckner; Jung
1980 , vol. No. 1, p. 37 - 49
反应条件
hydrogenchloride in ethyl acetate
T=0°C; 2 h;
参考文献
Tamiaki; Kiyomori; Maruyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 9 p. 2478 - 2486
反应条件
hydrogenchloride; hydrogen; palladium in methanol
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
参考文献
Perlman, Nurit; Hazan, Maya; Shokhen, Michael; Albeck, Amnon
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 9032 - 9039
反应条件
1: 90 percent / pyridine / 3 h / Ambient temperature
2: 55 °C / thermitase, H2O, pH 8.0
View Scheme
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
